DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and RGD1561277

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006246593.2	Gene:	RGD1561277 / 691468	RGDID:	1561277	Length:	910	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	165/665 - (24%)
Similarity:	262/665 - (39%)	Gaps:	147/665 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NSHFLDLHHPNCWPSEMAQIR---LQ----FANWNLKISPN------------DG----LPQKIC 63
            |:.|...|...|.|||.:.::   ||    ..|.:.|:..|            :|    ||...|
  Rat   300 NTEFEQQHFQYCRPSEASHVKPVWLQKTFPMRNPSSKLRDNSQQLEKLALPAKEGTRAQLPAFEC 364

  Fly    64 SDCFTKFCS----INAFRLACQEA------------QLKL---------SHIYDKID-------- 95
            ..|...||.    ...|::..::.            |.||         ..:|.:.:
  Rat   365 QVCGKLFCKNSHLTQHFKMHKEKCYRGNNCGPILNIQSKLPTYQSLGVGEELYTRDEAGKYICQK 429

  Fly    96 -ASSLEDDEIGQEDL----------------EPAEEHQETE-TTKPTTTVSAE--TQPN------ 134
             |.|::...||...:                .|.::.:..: :.||.:..:..  |.|:
  Rat   430 SAKSIQQKIIGDGRIVCGKTVCSKLNFSVQQNPRKDEKSHDFSGKPISKSNLHELTTPHRYERVH 494

  Fly   135 -----NTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLR 194
                 ..|.:|............||:..|.|:.||  .:.|..|.......     .|.|..|
  Rat   495 ECSACGKAFNPTPHVYSHSGAHPAEKPYECEDCQQ--SKLVGHPPAHAQEK-----RYVCHVC-- 550

  Fly   195 PQENYQLQQLLLEHINA---SHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            .:..|:     ..|::|   :|..|:||:|.||...|:..:...||.:....||..||..|||.:
  Rat   551 GKAFYK-----RAHLHAHQRTHTGEKPYDCKECGKSFRLKSFLVVHQRIHTGEKPFACDTCGKSF 610

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ..|.:|..|:..:..|..:||..|.|.|..:..|..|.:.|:.::.:.|  ..|.:.|....||.
  Rat   611 KQRTSLYTHIRIHTGEKPYECKECRKSFILKSYLTVHQRTHSGEKPYGC--DICGKSFKQNSHLH 673

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE 386
            .|:.||   :|.|...|..|||::....:|..| .:.|..||||:|..|.:.|:    .:.| |.
  Rat   674 AHKRTH---TSEKPYECIVCGKSYKQSPSLYTH-KKVHTSEKPYECKQCRKSFS----LKFH-LT 729

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDL-IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--L 448
            ||:...:.....:|.:|.:.|....:| :||                          |.::|  .
  Rat   730 RHQRTHSGGRTYQCKVCGKAFKHTQNLYLHH--------------------------RTHTGEKP 768

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|::||.|..|...|: .::|:.|..|...|||..|:..|.:.|..|||..|..|.|
  Rat   769 YECKECKKLFSVKSNLSVHQKTHT-GEKPYECNICRNAFKRRCDLTIHQRVHTGEKPYECKECRK 832

  Fly   514 AFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKL 578
            .|::|..|..|:..| ..||.::|||||:.:..:.:|..|::.|||:..::|..|.:.|.....|
  Rat   833 TFSIKSGLIVHQRIH-TGEKPYECNVCGKRFNQKSNLSTHEKIHTGEKPFECKDCSKAFSVKSYL 896

  Fly   579 KTHMQKAHAASQPHS 593
            ..| ||.|...:|||
  Rat   897 TIH-QKTHLGEKPHS 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	21/103 (20%)
		COG5048	198..>508	CDD:227381	88/315 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
RGD1561277	XP_006246593.2	KRAB	123..182	CDD:214630
		C2H2 Zn finger	364..384	CDD:275370	5/19 (26%)
		C2H2 Zn finger	496..539	CDD:275368	10/44 (23%)
		zf-C2H2	545..567	CDD:395048	6/28 (21%)
		C2H2 Zn finger	547..567	CDD:275368	5/26 (19%)
		COG5048	571..910	CDD:227381	112/378 (30%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..623	CDD:275368	7/19 (37%)
		C2H2 Zn finger	631..651	CDD:275368	6/19 (32%)
		C2H2 Zn finger	659..679	CDD:275368	6/21 (29%)
		C2H2 Zn finger	687..707	CDD:275368	6/20 (30%)
		C2H2 Zn finger	715..735	CDD:275368	7/24 (29%)
		C2H2 Zn finger	743..763	CDD:275368	7/45 (16%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		C2H2 Zn finger	799..819	CDD:275368	7/19 (37%)
		C2H2 Zn finger	827..847	CDD:275368	7/19 (37%)
		C2H2 Zn finger	855..875	CDD:275368	7/19 (37%)
		C2H2 Zn finger	883..903	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100