DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and LOC691170

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_001077082.3	Gene:	LOC691170 / 691170	RGDID:	1587418	Length:	669	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	166/653 - (25%)
Similarity:	270/653 - (41%)	Gaps:	139/653 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDAS-- 97
            |..:..:..:|..|.:..:....||    ..|.|:           .|..:||.|.::....|
  Rat    56 PELILMLEREFGPWRVADTSIWNLP----GYCITR-----------PELNIKLQHGFEPWSGSEA 105

  Fly    98 ---SLED----DEIGQEDLEPAEEH-QETETTKPTTT----VSAETQ------------------ 132
               :|.|    ..:|.:     |.| .:.|.|...|:    |.||.|
  Rat   106 SLWNLPDVHNVSALGNQ-----ETHLWQAEVTGGITSYEQMVEAELQIQEKIHRGAKTCEYKECV 165

  Fly   133 ----PN--NTASDPIEIFVDAVDIDEAEEE---EEEEEQQQQY---DEEVEEPITDESAP--PQL 183
                ||  :|.:...:.:.:|...:|.::.   :....|.|::   ::..:.|...|..|  .||
  Rat   166 ETFYPNAQHTRNQTSQSYENAYGWEECKKTFYYQSTLTQHQRFHIGEKLYDSPQCWEIFPWKSQL 230

  Fly   184 TI---------SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLK 239
            ::         .|.|:.|   ::::..:..|:.|...:|..|:||.|.||...|...:..|.|.:
  Rat   231 SVHETFHAGERRYECEEC---RKSFHRKANLIRHQRRTHSREKPYECIECGKTFYCKSDVTRHQR 292

  Fly   240 SSHV-EKQHACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQ 302
            .:|. ||.:.|..|.|.:..:..|..|..:.|| |..:||..|.|.||.:..|..|...|:.::.
  Rat   293 RTHSREKPYECVECSKTFYCKSYLIRHQSRTHSREKPYECTECTKTFYCKSDLTRHQTTHSGEKP 357

  Fly   303 FKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
            |:|..  |.:.|..:..|..|:.||:..:..:   |..|.|||....:|..| :|.|.|||||:|
  Rat   358 FECNE--CSKTFYYKSDLANHQKTHTDDNPYE---CKECRKTFCSKSSLNQH-HRIHTGEKPYEC 416

  Fly   368 ANCTEVFASYA-----EKRIHMLERH------------RENLTAIERS-------ECMLCRQPFS 408
            ..|.:.|.|.:     ::|.|..|:.            |..||..:|:       ||..||:.|.
  Rat   417 NECKKSFNSKSNLTEHQRRTHTREKPYECSECWKSFYCRSELTNHQRTHTVERFYECKECRKNFY 481

  Fly   409 SEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSE 473
            .:.:|..|......::|                       ::|..|::.|..||.|.:|...|:
  Rat   482 CKSNLNQHQRTHTGEKP-----------------------YECKDCNKAFYCKSNLNQHQRTHT- 522

  Fly   474 KDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCN 538
            .::|.||..|||.|.....:..|.|.|..|||..|:.|.|.|..|..||:|:.:| ..||.::|.
  Rat   523 GEKPFACKDCSKAFYCKSSLVKHQKIHSGEKPYECEECRKTFFQKSDLTRHQRTH-TGEKPYECT 586

  Fly   539 VCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH---SADQPLDD 600
            .|.:.:..:.:|..|:||||.:..|:|:.|:|.|.:..:|..| |:.|...:|:   :.|..||.
  Rat   587 DCSKTFYCKSNLNQHRRTHTHEKPYECEECREAFYSKSELTEH-QRTHTDEKPYVMFNIDCQLDK 650

  Fly   601 LIN 603
            :.|
  Rat   651 IWN 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	8/51 (16%)
		COG5048	198..>508	CDD:227381	94/335 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/21 (24%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
LOC691170	XP_001077082.3	KRAB	10..69	CDD:214630	2/12 (17%)
		KRAB	10..49	CDD:279668
		C2H2 Zn finger	190..209	CDD:275368	3/18 (17%)
		C2H2 Zn finger	218..237	CDD:275368	5/18 (28%)
		COG5048	243..617	CDD:227381	118/407 (29%)
		C2H2 Zn finger	245..266	CDD:275368	4/23 (17%)
		C2H2 Zn finger	274..295	CDD:275368	6/20 (30%)
		C2H2 Zn finger	303..324	CDD:275368	5/20 (25%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	5/21 (24%)
		C2H2 Zn finger	388..408	CDD:275368	8/20 (40%)
		zf-H2C2_2	400..425	CDD:290200	12/25 (48%)
		C2H2 Zn finger	416..437	CDD:275368	5/20 (25%)
		C2H2 Zn finger	445..465	CDD:275368	4/19 (21%)
		C2H2 Zn finger	473..493	CDD:275368	6/19 (32%)
		zf-H2C2_2	485..508	CDD:290200	5/45 (11%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
		zf-H2C2_2	513..536	CDD:290200	9/23 (39%)
		C2H2 Zn finger	529..549	CDD:275368	7/19 (37%)
		C2H2 Zn finger	557..577	CDD:275368	8/19 (42%)
		zf-H2C2_2	569..592	CDD:290200	8/23 (35%)
		C2H2 Zn finger	585..605	CDD:275368	5/19 (26%)
		C2H2 Zn finger	613..633	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000