DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp758

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006228150.1	Gene:	Zfp758 / 690559	RGDID:	1594701	Length:	659	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	152/596 - (25%)
Similarity:	234/596 - (39%)	Gaps:	101/596 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CRTCAISMFVC-------DFENGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQK 61
            |:.|...:..|       :...|...|:..:|...  :.|:. ::.|:...|..|:     ....
  Rat   130 CKNCVNCLSSCSTVSLTQEIHRGKKESNGTELDKD--FYSKQ-KLMLKQTKWGKKL-----YKCS 186

  Fly    62 ICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTT 126
            .|:.||.|.|   .||      :.:..|..:||......|....|:  .....||.....|
  Rat   187 ECAKCFAKKC---WFR------KHQTIHTGEKIYKCRECDKHFTQK--RNLIIHQRCHGGK---- 236

  Fly   127 VSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKF 191
                 :|.. .|:..:.|:...|:           ::.|.....|:|             |.|..
  Rat   237 -----KPYK-CSECEKCFIQVGDL-----------RRHQRIHTGEKP-------------YKCSE 271

  Fly   192 CLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            |   .:.:..:..|..| ...|..|:||.|.||:..|....|.::|.:....||.:.|..|.|.:
  Rat   272 C---DKCFSYKSSLRSH-QIIHTGEKPYKCNECDKCFTHKGSLSIHQRIHTGEKPYKCHECDKCF 332

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ..:.:|..|...:..|..::|:.|:|.|..:.||..|...|...:.:||  |.|::.|..:..|.
  Rat   333 TQKGSLITHQRIHTGEKPYKCSECDKGFTLKCSLIIHQIIHTGKKAYKC--SECDKCFTLKCDLS 395

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE 386
            .|:..|:|   .|...|..|.|.|.....||.| ...|.|||||||:.|.:.|......|||. .
  Rat   396 IHQRIHTG---EKLYRCNECDKCFTKKYRLRSH-QTIHTGEKPYKCSECDKSFTLKCHLRIHQ-R 455

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            .|    |..:..:|..|.:.|:.:..|..|......::|                       ::|
  Rat   456 IH----TGEKPYKCSECDKYFTQKGGLSTHQKIHAGEKP-----------------------YRC 493

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.:..||.|..|..:|. .::|:.|..|.|.|.....:|.|.:.|...||..|..|.|:||
  Rat   494 SKCDKCYTRKSHLSVHQRIHI-GEKPYKCNECDKCFTDKYCLKTHQRIHSGNKPYKCSECDKSFA 557

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ||..|..|::.| ..||.:||:.||:.:..:.||.:|||.|||:..|||..|.:.|.....|..|
  Rat   558 LKARLKSHQIIH-TGEKPYKCSKCGKYFTQKGSLSIHQRIHTGEKPYKCSECDKCFTRKSSLNVH 621

  Fly   582 MQKAHAASQPH 592
             |:.|...:|:
  Rat   622 -QRIHTGEKPY 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/89 (19%)
		COG5048	198..>508	CDD:227381	83/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp758	XP_006228150.1	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	185..205	CDD:275368	7/28 (25%)
		COG5048	209..634	CDD:227381	134/500 (27%)
		C2H2 Zn finger	213..233	CDD:275368	4/21 (19%)
		C2H2 Zn finger	241..261	CDD:275368	4/30 (13%)
		zf-H2C2_2	253..278	CDD:290200	7/51 (14%)
		C2H2 Zn finger	269..289	CDD:275368	4/23 (17%)
		zf-H2C2_2	281..306	CDD:290200	10/25 (40%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..334	CDD:290200	7/24 (29%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	6/21 (29%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		C2H2 Zn finger	437..457	CDD:275368	6/20 (30%)
		zf-H2C2_2	449..474	CDD:290200	8/29 (28%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		C2H2 Zn finger	549..569	CDD:275368	9/19 (47%)
		zf-H2C2_2	562..586	CDD:290200	9/24 (38%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..614	CDD:290200	13/24 (54%)
		C2H2 Zn finger	605..625	CDD:275368	6/20 (30%)
		zf-H2C2_2	617..642	CDD:290200	5/16 (31%)
		C2H2 Zn finger	633..653	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100