DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp526

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006228576.1	Gene:	Zfp526 / 687127	RGDID:	1588959	Length:	698	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	148/661 - (22%)
Similarity:	236/661 - (35%)	Gaps:	181/661 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FVCDFENGS-----------NNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSD 65
            |:|. |.||           ...|.|.:       ||...:..|......::.|:.|.....|.:
  Rat    87 FMCS-ECGSLYNTLEEVLSHQEQHLLTM-------SEEETLTTQDTGLESELVPSTGEGPFQCGE 143

  Fly    66 CFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE----HQET-------- 118
            |.....|.:.. ||.|:|.|:.|       ||.::......::|.|:.|    |::|
  Rat   144 CSQLILSPSEL-LAHQDAHLQES-------ASQIQYQCGDCQELFPSPELWVAHRKTQHLSSAAD 200

  Fly   119 ETTKPTTTVSAETQPNNTASDPIE-------------------IFVDAVDIDE---AEEEEEEEE 161
            |...|....:....|.....:|.|                   ...|:::.:|   .|||.|:||
  Rat   201 EPPPPLPPPNPPPPPPEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEGEDEE 265

  Fly   162 QQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEA 226
            ::.:.:|:.:|...:|....:||....                  |...::.||.:  :|.:|..
  Rat   266 EEGEEEEDDDEETDEEETSTELTADDT------------------EGDRSTADPAR--SCGDCPQ 310

  Fly   227 RFQDAASRTVHLKSSH--VEKQHA--CGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTR 287
            ....:.:|..|.::||  ....|.  |..|.:.:...:.|..| .:.|....:||..|.|.|...
  Rat   311 HCTSSGARRKHRRASHGPASATHPFHCSQCQRSFSSANRLVAH-GRAHVGGTYECTTCSKVFKKA 374

  Fly   288 KSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLR 352
            .||..|.:.|..:.::.|  ..|.|.|.::..|:.|...|:.....:..    |||||.::....
  Rat   375 ASLEQHQRLHRGEARYLC--VDCGRGFGTELTLVAHRRAHTANPLHRCR----CGKTFSNMTKFL 433

  Fly   353 WHIYRQHGGEK--PYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIH 415
            :| .|.|.|:.  |.|.|..:                                  |..:||
  Rat   434 YH-RRTHTGKSGTPTKVATVS----------------------------------PAPAEP---- 459

  Fly   416 HMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERH-AAVHSEKDRPHA 479
                  ...|..|                 .....|..|.:.|...|.|.|| .|||...:|.|.
  Rat   460 ------TPMPPPP-----------------PAQLPCPQCPKSFASASRLSRHRRAVHGPPERRHR 501

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.||:...::.|::||..|:|..|..|||.||....|::|:|:|..: :.::|..||:.:
  Rat   502 CGVCGKGFKKLVHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTHTGV-RPYQCLDCGKRF 565

  Fly   545 LFEKSLRLHQRTH--------------TG---KTYYKCDLCQERFVTHIKLKTHMQKAHAAS--- 589
            ....:|:.|:|.|              ||   |:.|.|..|...|.....|:.| |:.||.:
  Rat   566 TQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLH-QRVHARARSL 629

  Fly   590 --QPHSADQPL 598
              ||..:..|:
  Rat   630 TLQPPRSPSPV 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	20/85 (24%)
		COG5048	198..>508	CDD:227381	70/316 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	8/20 (40%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp526	XP_006228576.1	C2H2 Zn finger	89..109	CDD:275368	4/20 (20%)
		C2H2 Zn finger	141..161	CDD:275368	6/20 (30%)
		C2H2 Zn finger	173..192	CDD:275368	4/18 (22%)
		C2H2 Zn finger	305..325	CDD:275368	4/19 (21%)
		C2H2 Zn finger	337..357	CDD:275368	4/20 (20%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	392..412	CDD:275368	6/21 (29%)
		C2H2 Zn finger	420..439	CDD:275368	7/23 (30%)
		C2H2 Zn finger	474..492	CDD:275368	6/17 (35%)
		COG5048	<476..578	CDD:227381	36/102 (35%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		zf-H2C2_2	514..539	CDD:290200	10/24 (42%)
		C2H2 Zn finger	530..550	CDD:275368	9/19 (47%)
		zf-H2C2_2	542..567	CDD:290200	7/25 (28%)
		C2H2 Zn finger	558..578	CDD:275368	6/19 (32%)
		C2H2 Zn finger	603..623	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100