DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp59

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_008757435.1	Gene:	Zfp59 / 685610	RGDID:	1591403	Length:	686	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	150/653 - (22%)
Similarity:	228/653 - (34%)	Gaps:	204/653 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEI-------------FVDAVDID 151
            |.|.: ..|||...|.||........|::...|.....|:..|:             |....|..
  Rat    80 ETDRL-SPDLESEYETQELFPDNHIYTINLFKQTIRHISETFELKGSSFSNGHSYSTFRGLQDCQ 143

  Fly   152 EAEEEEEEEEQQQ---------------------------------QYD--EEVEEPITDESAPP 181
            |.:.:::...:::                                 ||.  ..||:|
  Rat   144 EGDVDQKNTNKEKVPTYTCHTLTHSLEKLYECKEYGKYFGCSSTLTQYQSIHSVEKP-------- 200

  Fly   182 QLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHV-EK 245
                 |.||.|   .:.:::||.|..|:|| |..|:|:.|.||...|:..:|...| |..|. .|
  Rat   201 -----YECKDC---GKAFKIQQHLTRHLNA-HSGERPFECSECGKSFKHDSSLVQH-KFIHAGVK 255

  Fly   246 QHACGVCGKKYGDRHNLRHHVEKYH---------------------------------------- 270
            ...|..|||.:..|.|...| :|.|
  Rat   256 PFECNECGKAFNRRSNFMRH-QKVHSDKKPFQYKEYGNVLNVLAELITQPRNIHTGKKSFECKQC 319

  Fly   271 ------------------SETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQ 317
                              ||..|.|.:|.|.|..:..|:.|.|.|..::.|:|:.  |..:|..:
  Rat   320 GKIFNSGSYLMQHQNIHTSEKAFGCNVCGKAFRLQAYLSEHQKTHTDEKPFQCKL--CGSVFRRK 382

  Fly   318 RHLMCHEATHSGTSSRKSEHCG-------------------------FCGKTFIHLKTLRWHIYR 357
            .||..|:..|:.....:.|.||                         .||..| .|::|.....|
  Rat   383 YHLTEHQRIHTDVKLYQCEECGKFFRRRSNFIEHQSIHSNVKPYKCKLCGLDF-RLQSLLNQHQR 446

  Fly   358 QHGGEKPYKCANCTEVF---ASYAE-KRIH-------------------MLERHRENLTAIERSE 399
            .|..||||:|..|.:.|   ::|.| :.||                   :|.:|:...|..:..|
  Rat   447 IHTDEKPYQCKECGKFFRRRSNYTEHQSIHTNVKPYKCNLCGTAFRLQSLLTQHQRIHTGEKPYE 511

  Fly   400 CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSAL 464
            |..|.:.|....:.|.|.|.....:|                       ::|..|...|.::|.|
  Rat   512 CKECGKFFRRSSNFIEHRSIHSNVKP-----------------------YKCKLCGSDFRLQSLL 553

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            .:|..:|: .::|:.|..|.|.|:|..:...|...|...||..|.:||.||.|:.:||||:..|
  Rat   554 NQHQRIHT-GEKPYQCKECGKFFRRRSNYTEHQSIHSNVKPFTCKLCGLAFRLQSLLTQHQRIH- 616

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSA 594
            ..||.::|..||:.:....:...||..|||:..:.|..|.:.|..:|.|..| |:.|......|.
  Rat   617 TGEKPYQCKECGKFFRRSSNFTEHQSVHTGEKPFDCKKCGKAFRLNIHLIRH-QRFHNGENAKSV 680

  Fly   595 DQP 597
            ::|
  Rat   681 ERP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	95/416 (23%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/45 (18%)
		C2H2 Zn finger	367..384	CDD:275368	7/39 (18%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp59	XP_008757435.1	KRAB	14..75	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368	2/19 (11%)
		COG5048	199..635	CDD:227381	116/482 (24%)
		C2H2 Zn finger	203..223	CDD:275368	9/23 (39%)
		C2H2 Zn finger	231..251	CDD:275368	7/20 (35%)
		C2H2 Zn finger	259..279	CDD:275368	8/20 (40%)
		C2H2 Zn finger	316..336	CDD:275368	0/19 (0%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..392	CDD:275368	6/21 (29%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	428..448	CDD:275368	6/20 (30%)
		C2H2 Zn finger	456..476	CDD:275368	5/19 (26%)
		C2H2 Zn finger	484..504	CDD:275368	2/19 (11%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)
		C2H2 Zn finger	568..588	CDD:275368	6/19 (32%)
		C2H2 Zn finger	596..616	CDD:275368	10/19 (53%)
		C2H2 Zn finger	624..644	CDD:275368	5/19 (26%)
		C2H2 Zn finger	652..672	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100