DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp442

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011238043.1	Gene:	Zfp442 / 668923	MGIID:	3651999	Length:	673	Species:	Mus musculus

Alignment Length:	567	Identity:	150/567 - (26%)
Similarity:	231/567 - (40%)	Gaps:	107/567 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPA--EEHQETETTK---- 122
            ::|...|...|:.:      :.|..|..:|:    .|.::.|.:..:.:  ::|:...|.|
Mouse   140 NECGKAFACHNSLQ------RYKRVHTGEKL----YECNQCGTDFAQHSHLQQHERMHTVKCKQS 194

  Fly   123 ----PTTTVSAETQPNNTASDPIE-IFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQ 182
                ...|.....|..:|...|.| ||.|...|..:..|..|.....      |:|
Mouse   195 GKDFACYTNLQIYQRTHTGEKPYECIFCDKTFIHHSHLERHERIHTG------EKP--------- 244

  Fly   183 LTISYACKFCLRP-QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQ 246
                |.|..|.:. .:|..||.    | ..:|..|:||.|.:|...|...:....|.|:.|.||.
Mouse   245 ----YECNQCGKAFSQNSSLQL----H-KRTHTGEKPYECKQCGKSFACQSGLQQHKKTHHGEKS 300

  Fly   247 HACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR----- 306
            :.|..|||.:..:.:|:.|...:..|..:||..|:|.|..|..|..|.:.|..::.:||.
Mouse   301 YECKRCGKAFACQSDLQQHKRTHTGEKSYECNQCDKAFALRCHLRRHQRIHTVEKPYKCNQCGKF 365

  Fly   307 -------------HSG--------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
                         |:|        |::.|..|..|:.|:.||||   .|...|..|||.|:....
Mouse   366 FAQSNHFVRHKRTHTGEKPYECNQCDKAFACQTSLLYHKRTHSG---EKLYVCNECGKAFVLQSY 427

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIH 415
            |:.| .|.|.||||:.|..|.:.||    :..|:| .|:...|..:..||..|.:.|:|..:|..
Mouse   428 LQIH-KRTHTGEKPFGCDQCDKAFA----QNSHLL-THKRTHTGEKPYECEQCGKAFASNSNLQV 486

  Fly   416 HMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHAC 480
            |......::|                       ::|..|.:.|..:|.|::|...|: .::|:.|
Mouse   487 HKKTHTGEKP-----------------------YECKQCGKAFGFQSGLQKHKRTHT-GEKPYEC 527

  Fly   481 PHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYL 545
            ..|.|.|.....:..|.::|..|||..|..|||||.|...|..|:..| ..||.|:|:.|.:|:.
Mouse   528 NQCDKAFACQASLLNHKRSHTGEKPYECSECGKAFVLHSYLQIHKRIH-TGEKPFECDQCDKAFA 591

  Fly   546 FEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ....|..|:|.|||:..|.|..|.:.|..|..|:.| ::.|...:|:
Mouse   592 RNTLLLKHKRIHTGQKPYGCKQCGKAFANHSNLQVH-KRTHTGEKPY 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	3/22 (14%)
		COG5048	198..>508	CDD:227381	92/335 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/47 (17%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp442	XP_011238043.1	KRAB	10..50	CDD:366587
		C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	140..159	CDD:275368	4/24 (17%)
		C2H2 Zn finger	167..183	CDD:275368	1/15 (7%)
		C2H2 Zn finger	191..211	CDD:275368	2/19 (11%)
		COG5048	215..595	CDD:227381	121/437 (28%)
		C2H2 Zn finger	219..239	CDD:275368	6/19 (32%)
		C2H2 Zn finger	247..267	CDD:275368	6/24 (25%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		C2H2 Zn finger	331..351	CDD:275368	7/19 (37%)
		C2H2 Zn finger	359..379	CDD:275368	1/19 (5%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	8/20 (40%)
		C2H2 Zn finger	443..463	CDD:275368	7/24 (29%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		SFP1	<577..660	CDD:227516	21/62 (34%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		C2H2 Zn finger	611..631	CDD:275368	6/20 (30%)
		C2H2 Zn finger	639..658	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100