DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and BC024063

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001360962.1	Gene:	BC024063 / 666584	MGIID:	2670978	Length:	749	Species:	Mus musculus

Alignment Length:	465	Identity:	139/465 - (29%)
Similarity:	207/465 - (44%)	Gaps:	67/465 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFC---LRPQENYQLQQLL---------------------LEHINASHDPEQPYNCPECEAR 227
            |.|..|   .....|.|:.:::                     ||....:|..|:||.|.:|...
Mouse   218 YCCHECGKAFATHNNLQIHEIIHTGEKPYECNECGRAFAYSRALEAHEKTHTGEKPYECNQCSKA 282

  Fly   228 FQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNY 292
            |...||...|||....||...|..|||.:..:..|..|...:..|..:||:.|.|.|..:..|..
Mouse   283 FASHASLRNHLKHHTGEKFFVCTQCGKAFTSQSILHRHERTHTGEKPYECSQCGKAFALQSYLQI 347

  Fly   293 HMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYR 357
            |.:.|..::.::|.|  |.:.|.|..:|..||..|:|   .|...|..|||.|:...:|:.| .|
Mouse   348 HKRTHTGEKPYECNH--CGKAFTSHANLQNHEKHHTG---EKPYGCNQCGKAFVCSSSLQIH-ER 406

  Fly   358 QHGGEKPYKCANCTEVFASYA----EKRIHMLER------------HRENLTAIERS-------E 399
            .|.|.|||:|..|.:.|.|.:    .:|||..|:            :..:|...|||       |
Mouse   407 SHTGNKPYECNQCGKAFTSRSYIQIHERIHTGEKPYGCKQCGKAFAYSSSLQIHERSHTGEKLFE 471

  Fly   400 CMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRERQYSG--LFQCGSCSQ 456
            |..|.:.|:|...|..|......::|      |.   |...|...|..|:.::|  .:.|..|.:
Mouse   472 CTHCSKAFASRSYLRIHKRVHTGEKPYECNHCGE---AFASRGSLQNHEKHHTGEKPYGCNQCGK 533

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|..:|.|:.|..:|: .::|:.|..|.|.|...:|::.|.:.|..|||..|..|||||.....|
Mouse   534 VFARRSNLQIHERIHT-GEKPYGCKQCGKAFVLKRDLQIHERIHTGEKPYGCKQCGKAFVCSSSL 597

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            ..|..|| ..||..:||.||:|:.....|::|:|.|||:..|:|:||.:.||:|..|:.| ::.|
Mouse   598 KIHERSH-TGEKPCECNQCGKAFASRSYLQIHKRVHTGEKPYECNLCGKAFVSHSYLQVH-KRTH 660

  Fly   587 AASQPHSADQ 596
            ...:|:..:|
Mouse   661 TGQKPNECNQ 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	101/361 (28%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	7/16 (44%)
BC024063	NP_001360962.1	KRAB	4..44	CDD:366587
		C2H2 Zn finger	109..128	CDD:275368
		COG5048	132..489	CDD:227381	78/276 (28%)
		C2H2 Zn finger	136..156	CDD:275368
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	220..240	CDD:275368	4/19 (21%)
		C2H2 Zn finger	248..268	CDD:275368	2/19 (11%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		COG5048	312..736	CDD:227381	114/371 (31%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	8/21 (38%)
		C2H2 Zn finger	388..408	CDD:275368	8/20 (40%)
		C2H2 Zn finger	416..436	CDD:275368	5/19 (26%)
		C2H2 Zn finger	444..464	CDD:275368	3/19 (16%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	5/22 (23%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	6/19 (32%)
		C2H2 Zn finger	584..604	CDD:275368	8/19 (42%)
		C2H2 Zn finger	612..632	CDD:275368	8/19 (42%)
		C2H2 Zn finger	640..660	CDD:275368	8/20 (40%)
		C2H2 Zn finger	668..688	CDD:275368	1/3 (33%)
		C2H2 Zn finger	696..716	CDD:275368
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010