DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp991

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001077387.1	Gene:	Zfp991 / 666532	MGIID:	3701604	Length:	573	Species:	Mus musculus

Alignment Length:	577	Identity:	141/577 - (24%)
Similarity:	226/577 - (39%)	Gaps:	126/577 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LHHPNCWP--SEMAQIRLQFANWNLKISPNDGLPQKIC--SDCFTKFCSINAFRLACQEAQLKLS 88
            |..|.|.|  :......|||:| ..::.|.:  .:::|  :|      |:|:..|....:..:..
Mouse    94 LEAPQCTPYKTNHTSDALQFSN-QKRLKPRN--TKEVCKYND------SVNSLTLFSTISLNQGI 149

  Fly    89 HIYDKIDASSLEDDEIGQEDLEPA--EEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDID 151
            |:..|        ...|..:.|.|  .:|:            ...:.|||..:|.:    ....|
Mouse   150 HMQKK--------KHNGNAESEKAFISKHK------------VMVKRNNTGVNPYK----CSKFD 190

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPE 216
            :...:.::.:.||:...|.:...:.:|..           |...|.:..:.|       ..|..|
Mouse   191 KYLTQRDKLQSQQRIYHEKKHYRSSKSDK-----------CFTHQIDLSIHQ-------GIHAEE 237

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
            :.|.|.||:..|.......:|.:....||.:.|..|.|.:..:.:|..|...:..|..::|.:||
Mouse   238 KIYKCSECDKCFTHKFHLNIHQRIHTGEKPYKCSECDKCFTQKSHLNIHQRIHTGEKPYKCIVCE 302

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|..:.:|..|.:.|..|:.:||  |.|::.|..:.||..|:..|:|   .|...|..|.|:|.
Mouse   303 KCFTEKGNLRIHQRIHTGDKPYKC--SECDKCFTQKSHLNIHQRIHTG---EKPYKCSQCDKSFT 362

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ....||.| .|.|.|||||||:.|.:.|......|||
Mouse   363 ENGHLRIH-QRNHTGEKPYKCSRCDKSFTENGHLRIH---------------------------- 398

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEK 474
                                          :|.::|  .::|..|.:.|..|.:|..|..:|: .
Mouse   399 ------------------------------QRIHTGEKPYKCSECDKCFTKKFSLRIHQRIHT-G 432

  Fly   475 DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNV 539
            ::|:.|..|.|.|.....::.|.:.|..|||..|..|.|:|.....|..|:..| ..||.:||..
Mouse   433 EKPYKCSECDKCFTFKGSLRIHQRIHTGEKPYKCSECDKSFTENGCLRIHQRIH-TGEKPYKCTE 496

  Fly   540 CGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |.:.:.|:.|||:|||.|||:..|||..|.:.|....||:.| |:.|...:|:...:
Mouse   497 CDKCFTFKGSLRIHQRIHTGEKPYKCTECDKSFTEKGKLRIH-QRIHKGEKPYKCSE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	14/62 (23%)
		COG5048	198..>508	CDD:227381	77/311 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp991	NP_001077387.1	KRAB	12..52	CDD:396083
		C2H2 Zn finger	186..206	CDD:275368	3/19 (16%)
		C2H2 Zn finger	218..234	CDD:275368	3/33 (9%)
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		COG5048	266..>550	CDD:227381	100/350 (29%)
		C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..346	CDD:275368	7/21 (33%)
		C2H2 Zn finger	354..374	CDD:275368	8/20 (40%)
		C2H2 Zn finger	382..402	CDD:275368	7/77 (9%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..514	CDD:275368	9/19 (47%)
		C2H2 Zn finger	522..542	CDD:275368	7/20 (35%)
		C2H2 Zn finger	550..566	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100