DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF649

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_075562.2	Gene:	ZNF649 / 65251	HGNCID:	25741	Length:	505	Species:	Homo sapiens

Alignment Length:	512	Identity:	120/512 - (23%)
Similarity:	190/512 - (37%)	Gaps:	130/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DDEI---GQEDLEPAEEH------------------QETETTKPTTTVSAETQPNNTASDPIEIF 144
            :|||   ...::|.|::|                  :...|.|....::.:::..| ..:|.|..
Human    70 EDEIHSPAHPEIEKADDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQSRRYN-RKEPAEFN 133

  Fly   145 VDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHI 209
            .|...:         .:..:|...|:|.|   ||..|   ||...:|              |:|
Human   134 GDGAFL---------HDNHEQMPTEIEFP---ESRKP---ISTKSQF--------------LKH- 168

  Fly   210 NASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETD 274
            ..:|:.|:.:.|.:|...|...:..|.|.:....:|.|.|.:|||.:..::.|..|...:..|..
Human   169 QQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEKP 233

  Fly   275 FECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG 339
            ..|:||.|.||.|..|..|.:.|..::.:.|  |.|.:.|..:..|..|:..|:|.   |...|.
Human   234 HGCSLCGKAFYKRYRLTEHERAHKGEKPYGC--SECGKAFPRKSELTEHQRIHTGI---KPHQCS 293

  Fly   340 FCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCR 404
            .||:.|.....|..| .|.|.||||:.|:.|.:.|.......||
Human   294 ECGRAFSRKSLLVVH-QRTHTGEKPHTCSECGKGFIQKGNLNIH--------------------- 336

  Fly   405 QPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERH 467
                                                 :|.::|  .:.|..|.:.|:.||.|..|
Human   337 -------------------------------------QRTHTGEKPYGCIDCGKAFSQKSCLVAH 364

  Fly   468 AAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLE 532
            ...|:.| .|..||.|.:...:...:..|.|.|..|||..|..|||||..|.:|..|..:| ..|
Human   365 QRYHTGK-TPFVCPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVHHRTH-TGE 427

  Fly   533 KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAAS 589
            :.:.|:.|.:||.:...|..|:|.|:          :|:....:|::.....:|:.|
Human   428 RPYGCDECEKAYFYMSCLVKHKRIHS----------REKRGDSVKVENPSTASHSLS 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	75/311 (24%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	2/16 (13%)
ZNF649	NP_075562.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		zf-H2C2_2	193..215	CDD:290200	8/21 (38%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		COG5048	260..>321	CDD:227381	21/66 (32%)
		C2H2 Zn finger	264..284	CDD:275368	6/21 (29%)
		zf-H2C2_2	276..301	CDD:290200	9/27 (33%)
		C2H2 Zn finger	292..312	CDD:275368	7/20 (35%)
		zf-H2C2_2	305..329	CDD:290200	11/24 (46%)
		C2H2 Zn finger	320..340	CDD:275368	6/77 (8%)
		zf-H2C2_2	332..357	CDD:290200	7/82 (9%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		zf-H2C2_2	389..413	CDD:290200	12/23 (52%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..481		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000