DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Gm7072

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001344920.1	Gene:	Gm7072 / 631624	MGIID:	3648314	Length:	689	Species:	Mus musculus

Alignment Length:	633	Identity:	157/633 - (24%)
Similarity:	258/633 - (40%)	Gaps:	125/633 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SMFVC-DFENGSNNS------------------HFLD--LHHPNCWPSEMAQIR---LQFANWNL 50
            :.::| :|||..|..                  |.||  :|...........:|   ::.:|.:.
Mouse    54 NQYMCPEFENMLNQDLQHIVHEHANTQVKSYECHELDKIIHESTGSAPSKTNLRATSVESSNLSR 118

  Fly    51 KISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQED-----LE 110
            ..:.|:..|   |.|    ...:|.|.| |....|.             :...||:::     |:
Mouse   119 HETENNREP---CKD----KNHVNCFNL-CSTISLN-------------QGINIGKKEYNGAKLD 162

  Fly   111 PAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPIT 175
            ...:.:||...|.|.:|....:    .|:..:.|:...|:           ::.|...:.|:|
Mouse   163 KVFDSKETLILKQTKSVKKPYK----CSECEKCFIQVGDL-----------RKHQRIHKGEKP-- 210

  Fly   176 DESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKS 240
                       |.|..|   ::.:..:..|..| ...|..|.||.|.||:..|....|.::|...
Mouse   211 -----------YKCNEC---EKCFSYKSSLRTH-QRIHTGENPYKCSECDKCFSHKGSLSIHQMY 260

  Fly   241 SHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC 305
            ...:|.:.|..|.|.:....:||.|...:..|..::|..|||.|.::.:|..|.:.|..::.:||
Mouse   261 HTGKKPYKCSECEKCFIQVGDLRRHERIHTGEKPYKCNECEKCFSSKTNLRTHQRIHTGEKPYKC 325

  Fly   306 RHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC 370
              |.|::.|..:..|:.|:..|:|   :|...|..|.|.||.:..||.| .|.|.|||||||:.|
Mouse   326 --SECDKGFTLKCSLIIHQVYHTG---KKPYKCSECEKCFIQVGDLRKH-QRIHTGEKPYKCSEC 384

  Fly   371 TEVFASYAEKRIHMLERHRENLTAIERS-ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNK 434
            .:.|.......||      :.:.|.|:. .|..|.:.|:.:..||.|.           ||...:
Mouse   385 DKSFTQKGSLSIH------QRIHAGEKPYRCSECDKGFTLKCSLIIHQ-----------IIHTGE 432

  Fly   435 RVLQ--------------QKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHC 483
            :..:              :...|.::|  |::|..|.:.|..|..|..|..:|: .::|:.|..|
Mouse   433 KTYKCSECDKCFSHKGSLKVHLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHT-GEKPYKCSEC 496

  Fly   484 SKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEK 548
            .|.|....:::.|.:.|..|||..|..|.|.:..|..|..|:..| ..||.:||:.|.:.|..:.
Mouse   497 DKSFTLKGNLRDHQRIHTGEKPYKCSECDKYYTRKSHLIVHQKIH-AGEKPYKCSECDKYYTRKS 560

  Fly   549 SLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .|.:|||.|.|:..|||..|.:.|.....|:|| |:.|:|::|:...:
Mouse   561 HLIVHQRIHIGEKPYKCSECNKCFTNKYHLRTH-QRIHSANKPYKCSE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	20/100 (20%)
		COG5048	198..>508	CDD:227381	89/326 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Gm7072	NP_001344920.1	KRAB	13..52	CDD:396083
		C2H2 Zn finger	185..205	CDD:275368	4/30 (13%)
		COG5048	209..650	CDD:227381	124/442 (28%)
		C2H2 Zn finger	213..233	CDD:275368	4/23 (17%)
		C2H2 Zn finger	241..261	CDD:275368	6/19 (32%)
		C2H2 Zn finger	269..289	CDD:275368	6/19 (32%)
		C2H2 Zn finger	297..317	CDD:275368	7/19 (37%)
		C2H2 Zn finger	325..345	CDD:275368	6/21 (29%)
		C2H2 Zn finger	353..373	CDD:275368	9/20 (45%)
		C2H2 Zn finger	381..401	CDD:275368	5/25 (20%)
		C2H2 Zn finger	409..429	CDD:275368	7/30 (23%)
		C2H2 Zn finger	437..457	CDD:275368	1/19 (5%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		C2H2 Zn finger	493..513	CDD:275368	5/19 (26%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	7/20 (35%)
		C2H2 Zn finger	605..625	CDD:275368	0/3 (0%)
		C2H2 Zn finger	633..653	CDD:275368
		zf-H2C2_2	645..669	CDD:404364
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100