DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp970

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001171039.1	Gene:	Zfp970 / 628308	MGIID:	3652255	Length:	522	Species:	Mus musculus

Alignment Length:	484	Identity:	144/484 - (29%)
Similarity:	215/484 - (44%)	Gaps:	58/484 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 VSAETQPNNTA------SDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTI 185
            |..||..|.||      ...||   |......:....|.....:|:.|.:           |...
Mouse    32 VMVETYRNLTAIGYSWEEHTIE---DHFQTSRSHGRYERRSSAEQHSEFI-----------QCGK 82

  Fly   186 SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTV--HLKSSHV-EKQH 247
            ::||      |.:.|      .|:.. |:.|:.|.|.:|.   :|..:|:|  .||.:|. ||.:
Mouse    83 AFAC------QSHSQ------RHVRI-HNGEKHYECNQCG---KDFGTRSVLQRLKRTHTGEKPY 131

  Fly   248 ACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCER 312
            .|..|||.:.:...|:.|..|:..:..:||..|.|.|..|..|..|.:.|..::.::|..  |.:
Mouse   132 ECNHCGKAFAESSTLQIHKRKHTGDEPYECNHCVKAFAKRSDLQIHKRIHTGEKPYECNQ--CGK 194

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY 377
            .|....||..|:.||:|   .|...|..|||.|....||:.|.: .|.|||||:|..|.:.||..
Mouse   195 AFTRSSHLGIHKRTHTG---EKPYECKQCGKAFARSSTLQTHKH-THTGEKPYECKQCGKAFAQS 255

  Fly   378 AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANN---KRVLQQ 439
            ..     |:.|:...||.:..||..|.:.|:....|..|......::|......:.   ||...|
Mouse   256 GP-----LQIHKRTHTAEKPYECKQCGKAFAHSSTLQIHKRTHTGEKPYECKQCDKAFVKRGELQ 315

  Fly   440 KRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
            ..:|.::|  .::|..|.:.|.....|:.|...|: .::|..|..|.|.|.|...::.|.:||..
Mouse   316 IHKRTHTGEKPYECKQCGKAFAQSGTLQEHERTHT-GEKPFECNQCGKAFVRCIALRIHERTHTG 379

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDL 567
            |||..|..||||||....|..|..:| ..||.|:||.||:|::...:||:|:|||||:..|:|..
Mouse   380 EKPYECKQCGKAFAQSGTLQGHERTH-TGEKPFECNQCGKAFVQCIALRIHERTHTGEKPYECKQ 443

  Fly   568 CQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |.:.|.....|:.| ::.|...:|:...|
Mouse   444 CGKAFAHRSTLQIH-ERTHTGEKPYECKQ 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	93/317 (29%)
		C2H2 Zn finger	221..241	CDD:275368	7/21 (33%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp970	NP_001171039.1	KRAB	4..>45	CDD:214630	6/12 (50%)
		KRAB	4..43	CDD:279668	5/10 (50%)
		COG5048	75..477	CDD:227381	133/438 (30%)
		C2H2 Zn finger	79..97	CDD:275368	6/30 (20%)
		C2H2 Zn finger	105..125	CDD:275368	7/22 (32%)
		C2H2 Zn finger	133..153	CDD:275368	6/19 (32%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..198	CDD:290200	6/26 (23%)
		C2H2 Zn finger	189..209	CDD:275368	6/21 (29%)
		zf-H2C2_2	201..226	CDD:290200	12/27 (44%)
		C2H2 Zn finger	217..237	CDD:275368	8/20 (40%)
		zf-H2C2_2	230..254	CDD:290200	11/24 (46%)
		C2H2 Zn finger	245..265	CDD:275368	6/24 (25%)
		zf-H2C2_2	258..282	CDD:290200	8/23 (35%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..309	CDD:290200	3/22 (14%)
		C2H2 Zn finger	301..321	CDD:275368	4/19 (21%)
		zf-H2C2_2	313..338	CDD:290200	6/24 (25%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	8/24 (33%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	398..422	CDD:290200	11/24 (46%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	425..450	CDD:290200	12/24 (50%)
		C2H2 Zn finger	441..461	CDD:275368	5/20 (25%)
		zf-H2C2_2	454..478	CDD:290200	5/19 (26%)
		COG5048	465..>522	CDD:227381	2/7 (29%)
		C2H2 Zn finger	469..489	CDD:275368	1/3 (33%)
		zf-H2C2_2	482..506	CDD:290200
		C2H2 Zn finger	497..517	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100