DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp987

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001033015.1	Gene:	Zfp987 / 626316	MGIID:	3702694	Length:	633	Species:	Mus musculus

Alignment Length:	574	Identity:	148/574 - (25%)
Similarity:	253/574 - (44%)	Gaps:	76/574 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LQFANWNLKISPNDGLPQKICS-----DCFTKFCSINAFR-LACQEAQLKLSHIYDKIDASS--- 98
            |||:| ..::.|.:  .:::|.     :..:.|.:|:..: :..|:.:...:...|||..|.
Mouse   111 LQFSN-QKRLKPRN--TKEVCKYNDSVNSLSLFSTISLNQGINMQKKKHNRNAELDKIFVSKHKV 172

  Fly    99 -LEDDEIGQEDLEPAEEHQ---ETETTKPTTTVSAETQP-NNTASDPIEIFVDAVDIDEAEEEEE 158
             ::.|.|.....:.:|.|:   :.|..:....:....:| .::.||  :.|...:.:...:|...
Mouse   173 MVKKDNIAGNPYKCSEFHKYLTQRENLQSQQRIYHGKKPYKSSKSD--KCFTHQIHLSIHQEIHT 235

  Fly   159 EEE----------QQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASH 213
            ||:          .:.:::..:.:.|.....|.:.:   .|..|...|.|..:.|.:       |
Mouse   236 EEKIYKCSECDKCFKNKFNLTMHQRIHTGEKPYKCS---ECDKCFTKQSNLSIHQRI-------H 290

  Fly   214 DPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECA 278
            ..|:||.|.||:..|...:..::|.:....||.:.|..|||.:.::.:||.|...:..|..::|:
Mouse   291 TGEKPYKCSECDKCFTQESYLSIHQRIHTGEKPYKCSECGKCFTEKSSLRIHQRIHTGEKPYKCS 355

  Fly   279 LCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGK 343
            .|:|.|..:..|:.|.:.|..::.:||  |.|::.|..|.:|..|:..|:|   .|...|..|||
Mouse   356 ECDKCFTQQSHLSIHQRIHTGEKPYKC--SECDKCFTQQSNLSIHQRIHTG---EKPYKCSECGK 415

  Fly   344 TFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFS 408
            .|....:||.| .|.|.|||||||:.|.:.|...:..|||. ..|    |..:..:|..|.:.|:
Mouse   416 CFTEKSSLRIH-QRIHTGEKPYKCSECGKCFTEKSSLRIHQ-RIH----TGEKPYKCNECGKCFT 474

  Fly   409 SEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSE 473
            .:..|..|......::|                       ::|..|.:.|.:||:|..|..:|:
Mouse   475 EKSSLRIHQRIHTGEKP-----------------------YKCSECGKCFTVKSSLRIHQKIHT- 515

  Fly   474 KDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCN 538
            .::|:.|..|.|.|.:...:..|.:.|..|||..|..|.|.|..|.:|..|:..| ..|:.:||:
Mouse   516 GEKPYKCSECDKCFTKPSHLSIHQRIHTGEKPYKCSECEKCFNEKNILKIHQRIH-TGERPYKCS 579

  Fly   539 VCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            .|.:.:..:..|.:|||.||||..|||..|.:.|.....|..| ||.|...:|:
Mouse   580 ECDKCFSRKFHLGIHQRIHTGKKPYKCSECDKCFTQKSHLSIH-QKIHTGEKPY 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	9/49 (18%)
		COG5048	198..>508	CDD:227381	87/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp987	NP_001033015.1	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	186..206	CDD:275368	3/19 (16%)
		C2H2 Zn finger	218..234	CDD:275368	3/17 (18%)
		COG5048	238..611	CDD:227381	116/418 (28%)
		C2H2 Zn finger	242..262	CDD:275368	0/19 (0%)
		zf-H2C2_2	254..278	CDD:290200	4/26 (15%)
		C2H2 Zn finger	270..290	CDD:275368	5/29 (17%)
		zf-H2C2_2	282..307	CDD:290200	10/31 (32%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		zf-H2C2_2	310..334	CDD:290200	7/23 (30%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		zf-H2C2_2	338..363	CDD:290200	8/24 (33%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		zf-H2C2_2	366..391	CDD:290200	8/26 (31%)
		C2H2 Zn finger	382..402	CDD:275368	7/21 (33%)
		zf-H2C2_2	394..418	CDD:290200	9/26 (35%)
		C2H2 Zn finger	410..430	CDD:275368	9/20 (45%)
		zf-H2C2_2	422..446	CDD:290200	13/24 (54%)
		C2H2 Zn finger	438..458	CDD:275368	6/20 (30%)
		zf-H2C2_2	450..474	CDD:290200	7/28 (25%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		zf-H2C2_2	478..502	CDD:290200	5/46 (11%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		zf-H2C2_2	506..530	CDD:290200	7/24 (29%)
		C2H2 Zn finger	522..542	CDD:275368	5/19 (26%)
		zf-H2C2_2	534..558	CDD:290200	8/23 (35%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		zf-H2C2_2	563..587	CDD:290200	7/24 (29%)
		C2H2 Zn finger	578..598	CDD:275368	6/19 (32%)
		C2H2 Zn finger	606..626	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100