DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp872

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001028985.1	Gene:	Zfp872 / 619310	MGIID:	3588272	Length:	465	Species:	Mus musculus

Alignment Length:	484	Identity:	130/484 - (26%)
Similarity:	198/484 - (40%)	Gaps:	92/484 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 IDEAEEEEEEEEQQQQYDE--EVEEPITDESAPPQLTISYACK---------FCLRPQE------ 197
            :|::::|..::..|:..|.  .:.|...|:|...|      ||         ...||:|
Mouse    21 LDDSQKELYQDVMQETVDNLASIGENWQDQSIRDQ------CKTQGKYISAHVEQRPREWKSACR 79

  Fly   198 --NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLK--SSHVE--------KQHACG 250
              ..||..|..:||...   .:|..|..|...:...:|...|::  |.|.:        |.:.|.
Mouse    80 EVFTQLPALKQQHILPG---VKPCECGICGKVYSCRSSLKRHMQCHSEHTQWESHGFRGKLYQCK 141

  Fly   251 VCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI 315
            .|||.:..:.:.|.|...:..|..:.|..|.|.|....:...||:.|..::.:||:.  |.:.|.
Mouse   142 DCGKAFSFQSSFRIHERTHTGEKPYMCKECGKAFIYHTTYQGHMRMHTGEKPYKCKE--CGKAFS 204

  Fly   316 SQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFA---SY 377
            .......||..|||   .|...|..|||||.:.:|.:.| .|.|.|||||:|..|.:..:   |:
Mouse   205 HPSLFRNHERAHSG---EKPYECKQCGKTFRYYQTFQLH-ERTHTGEKPYQCKQCGKALSRSTSF 265

  Fly   378 -AEKRIHMLE------------------RHRENLTAIERS-ECMLCRQPFSSEPDLIHHMSAEHL 422
             :.:|||..|                  |..|.:...||. :|..|.:.|.|.|....|:    :
Mouse   266 RSHERIHTGEKPYKCRKCGKAFRFPSSFRKHERIHTDERPYDCKECGKAFISLPSFRRHV----I 326

  Fly   423 QRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRF 487
            ...|                   :|.::|..|.:.|:..|:...|...|: .::||.|..|.|.|
Mouse   327 LHTG-------------------NGPYKCKECGKAFDCPSSFHIHERTHT-GEKPHECQRCGKAF 371

  Fly   488 KRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRL 552
            ..|..::.|.:||..|||..|..|||||:.......|...| ..||.::|..||:|:.|..|.|:
Mouse   372 SCASSVRIHERTHTGEKPYECKQCGKAFSSSSSFRMHERIH-TGEKPYECRQCGKAFSFSSSFRM 435

  Fly   553 HQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            |:|||.|:..|:|..|.:.|.:......|
Mouse   436 HERTHKGEKPYECKQCGKAFSSSSSFHMH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/342 (26%)
		C2H2 Zn finger	221..241	CDD:275368	4/21 (19%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/17 (24%)
Zfp872	NP_001028985.1	KRAB	4..>44	CDD:214630	4/22 (18%)
		KRAB	4..43	CDD:279668	4/21 (19%)
		C2H2 Zn finger	78..94	CDD:275368	4/15 (27%)
		C2H2 Zn finger	102..122	CDD:275368	4/19 (21%)
		C2H2 Zn finger	140..160	CDD:275368	6/19 (32%)
		zf-H2C2_2	152..177	CDD:290200	7/24 (29%)
		COG5048	164..>449	CDD:227381	93/315 (30%)
		C2H2 Zn finger	168..188	CDD:275368	6/19 (32%)
		zf-H2C2_2	184..205	CDD:290200	7/22 (32%)
		C2H2 Zn finger	196..216	CDD:275368	5/21 (24%)
		C2H2 Zn finger	224..244	CDD:275368	9/20 (45%)
		C2H2 Zn finger	252..272	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..287	CDD:290200	5/22 (23%)
		C2H2 Zn finger	280..300	CDD:275368	2/19 (11%)
		C2H2 Zn finger	308..328	CDD:275368	6/23 (26%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-H2C2_2	376..401	CDD:290200	12/24 (50%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		zf-H2C2_2	404..428	CDD:290200	8/24 (33%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100