DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF317

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_065984.3	Gene:	ZNF317 / 57693	HGNCID:	13507	Length:	595	Species:	Homo sapiens

Alignment Length:	608	Identity:	164/608 - (26%)
Similarity:	255/608 - (41%)	Gaps:	110/608 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ISMFVCDFENGSNNSHFLDLHHPNCWPSE---MAQIRLQFA--NWNLKISPNDGLPQKICSDCFT 68
            :.:|||   :|      |:.|.|:....|   ...:.:.|.  .|.|.    |...:|:..|...
Human    36 LDLFVC---SG------LEPHTPSVGSQESVTFQDVAVDFTEKEWPLL----DSSQRKLYKDVML 87

  Fly    69 KFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE----HQ------ETETTKP 123
            :..| |...|..|..:..|        .|.||.:|      ||..|    ||      ||.:...
Human    88 ENYS-NLTSLGYQVGKPSL--------ISHLEQEE------EPRTEERGAHQGACADWETPSKTK 137

  Fly   124 TTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQY-----DEEVEEPITDESAP-PQ 182
            .:.:..:.....|.|        .|.::.|...|:..|....:     |..:.:|:...:.. |.
Human   138 WSLLMEDIFGKETPS--------GVTMERAGLGEKSTEYAHLFEVFGMDPHLTQPMGRHAGKRPY 194

  Fly   183 LTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQH 247
            ....|...|..||.        |.:|: :.:|..:.:.|.:|:..|..:||.|.|.:....||.:
Human   195 HRRDYGVAFKGRPH--------LTQHM-SMYDGRKMHECHQCQKAFTTSASLTRHRRIHTGEKPY 250

  Fly   248 ACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCER 312
            .|..|||.:.|...||.|...:..|..|:|:.|...|.|..:|..||:.|..:|.:||  ..|.:
Human   251 ECSDCGKAFNDPSALRSHARTHLKEKPFDCSQCGNAFRTLSALKIHMRVHTGERPYKC--DQCGK 313

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASY 377
            .:....||:.|:.||:|   .:...|..|||.|.|...|:.|: |.|.|||||.|..|.:.|...
Human   314 AYGRSCHLIAHKRTHTG---ERPYECHDCGKAFQHPSHLKEHV-RNHTGEKPYACTQCGKAFRWK 374

  Fly   378 A----EKRIHMLERHRE------------------NLTAIERS-ECMLCRQPFSSEPDLIHHMSA 419
            :    .|:.||:|:..|                  .:..:::. ||..|.:.|.::..|..||::
Human   375 SNFNLHKKNHMVEKTYECKECGKSFGDLVSRRKHMRIHIVKKPVECRQCGKTFRNQSILKTHMNS 439

  Fly   420 EHLQRP------GAPIIANNKRVLQQK---RERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKD 475
            ...::|      |....|::.....:|   :||:|    :|.:|.:.|....:..||.:||..|.
Human   440 HTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERRY----ECAACGKVFGDYLSRRRHMSVHLVKK 500

  Fly   476 RPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVC 540
            |.. |..|.|.|:....:|.|:::|..|||..||.|||||::...|..||..| ..||.::|.||
Human   501 RVE-CRQCGKAFRNQSTLKTHMRSHTGEKPYECDHCGKAFSIGSNLNVHRRIH-TGEKPYECLVC 563

  Fly   541 GRAYLFEKSLRLHQRTHTGKTYY 563
            |:|:....|||.|.:||.|:..:
Human   564 GKAFSDHSSLRSHVKTHRGEKLF 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	18/82 (22%)
		COG5048	198..>508	CDD:227381	96/341 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF317	NP_065984.3	KRAB	57..109	CDD:214630	12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		8/24 (33%)
		COG5048	222..580	CDD:227381	115/369 (31%)
		C2H2 Zn finger	224..244	CDD:275368	7/19 (37%)
		C2H2 Zn finger	252..272	CDD:275368	8/19 (42%)
		C2H2 Zn finger	280..300	CDD:275368	7/19 (37%)
		C2H2 Zn finger	308..328	CDD:275368	5/21 (24%)
		C2H2 Zn finger	336..356	CDD:275368	9/20 (45%)
		C2H2 Zn finger	364..384	CDD:275368	4/19 (21%)
		C2H2 Zn finger	392..412	CDD:275368	0/19 (0%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	448..468	CDD:275368	3/19 (16%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275368	10/19 (53%)
		C2H2 Zn finger	560..580	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100