DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZFP14

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001284548.1	Gene:	ZFP14 / 57677	HGNCID:	29312	Length:	534	Species:	Homo sapiens

Alignment Length:	531	Identity:	151/531 - (28%)
Similarity:	218/531 - (41%)	Gaps:	88/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KIDASSLEDDEIGQEDLEPAEEHQ----ETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDE- 152
            |.|..:|.|:|..:..:...|..:    :.|:...|.|:|.|       .|..||:....||.|
Human    52 KPDVITLLDEERKEPGMVVREGTRRYCPDLESRYRTNTLSPE-------KDIYEIYSFQWDIMER 109

  Fly   153 -----------------AEEEEEEEEQQQQYDEEVEEPITDESAPP----------QLTIS---- 186
                             ..:.|.|:|||:.|..:|:  ||.|....          |:..:
Human   110 IKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVK--ITSEKMTTYKRHNFLTEYQIVHNGEKV 172

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.||.|   ::.:..:..|.:|:.. |..|:||.|.||...|:..|....|.|....||.:.|..
Human   173 YECKEC---RKTFIRRSTLSQHLRI-HTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKE 233

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
            |||.:.....|..|...:..|..:||..|.|.|...:.|..|.:.|..::.::|:  .|.:.|..
Human   234 CGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECK--DCGKTFRQ 296

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            ..||..|:..|   ::.|...|..|||.|:....||.| .:.|.|||||:|..|.:.|      |
Human   297 CTHLTRHQRLH---TAEKLYECKECGKAFVCGPDLRVH-QKIHFGEKPYECKECGKAF------R 351

  Fly   382 I-HMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQY 445
            | ..|..|:...|..:..||..|.:.|.....|:.|......::|
Human   352 ICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKP-------------------- 396

  Fly   446 SGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDV 510
               ::|..|.:.|:..|.|..|.::|. .:||:.|..|.|.|:....:..|...|..|||..|..
Human   397 ---YECMECWKTFSSYSQLISHQSIHI-GERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKE 457

  Fly   511 CGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTH 575
            |.|.|.|...||||:..| ..||.::|..||:|:.....|..|||.|||:..|||..|::.|..|
Human   458 CRKPFRLLSQLTQHQSIH-TGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQH 521

  Fly   576 IKLKTHMQKAH 586
            ..|..| ||.|
Human   522 SHLTQH-QKIH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	85/310 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZFP14	NP_001284548.1	KRAB	6..68	CDD:214630	5/15 (33%)
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368	5/23 (22%)
		zf-H2C2_2	188..212	CDD:290200	10/24 (42%)
		COG5048	199..534	CDD:227381	115/371 (31%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		zf-H2C2_2	215..239	CDD:290200	8/23 (35%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		zf-H2C2_2	243..266	CDD:290200	7/22 (32%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..296	CDD:290200	6/25 (24%)
		C2H2 Zn finger	287..307	CDD:275368	6/21 (29%)
		zf-H2C2_2	299..324	CDD:290200	10/27 (37%)
		C2H2 Zn finger	315..335	CDD:275368	8/20 (40%)
		zf-H2C2_2	327..350	CDD:290200	11/23 (48%)
		C2H2 Zn finger	343..363	CDD:275368	7/25 (28%)
		zf-H2C2_2	356..378	CDD:290200	6/21 (29%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		zf-H2C2_2	384..408	CDD:290200	6/46 (13%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		zf-H2C2_2	468..490	CDD:290200	10/22 (45%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		zf-H2C2_2	496..520	CDD:290200	12/23 (52%)
		C2H2 Zn finger	511..531	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100