DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF471

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_065864.2	Gene:	ZNF471 / 57573	HGNCID:	23226	Length:	626	Species:	Homo sapiens

Alignment Length:	627	Identity:	152/627 - (24%)
Similarity:	244/627 - (38%)	Gaps:	142/627 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WPSEMAQIRLQFANWNLKISPNDGLPQK------ICSDCFTKFCSINAFRLACQ--EAQLKLSHI 90
            |.......|..|::|. .|.....||.|      .|.:      .|.::.|.|.  |...|...:
Human    73 WEMTSEMTRSPFSDWE-SIYVTQELPLKQFMYDDACME------GITSYGLECSTFEENWKWEDL 130

  Fly    91 YDKIDASSLEDDEIGQEDLEPAEE---HQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDE 152
            ::|         ::|..::...:|   |:|        |::.||:...|.      |...:.:
Human   131 FEK---------QMGSHEMFSKKEIITHKE--------TITKETEFKYTK------FGKCIHL-- 170

  Fly   153 AEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQ 217
                           |.:||.|.:.::               .::::....::::| ...:..::
Human   171 ---------------ENIEESIYNHTS---------------DKKSFSKNSMVIKH-KKVYVGKK 204

  Fly   218 PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEK 282
            .:.|.||:..|..::|.|||.:....||.:||..|||.:..|.:|..|...:..|..|||..|.|
Human   205 LFKCNECDKTFTHSSSLTVHFRIHTGEKPYACEECGKAFKQRQHLAQHHRTHTGEKLFECKECRK 269

  Fly   283 RFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG-------- 339
            .|...:.|..|.:.|..::.:||:.  |.:.|....||..|:..|:|....:.:.||
Human   270 AFKQSEHLIQHQRIHTGEKPYKCKE--CRKAFRQPAHLAQHQRIHTGEKPYECKECGKAFSDGSS 332

  Fly   340 -----------------FCGKTFIHLKTL--RWHIY--------------------------RQH 359
                             .|||.|.:..:.  .|..|                          |.|
Human   333 FARHQRCHTGKRPYECIECGKAFRYNTSFIRHWRSYHTGEKPFNCIDCGKAFSVHIGLILHRRIH 397

  Fly   360 GGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQR 424
            .|||||||..|.:.|:|.:.:.:|. ..|    |..:..||.:|.:.||....|..|......::
Human   398 TGEKPYKCGVCGKTFSSGSSRTVHQ-RIH----TGEKPYECDICGKDFSHHASLTQHQRVHSGEK 457

  Fly   425 P-----GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCS 484
            |     .......|..::...|.......::|..|.:.|.:.|.|..|..:|: .::|:.|..|.
Human   458 PYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRIHT-GEKPYECIECG 521

  Fly   485 KRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKS 549
            ..||:...:..|.|||..|||..|:.|||||:....||||:..| ..||.:||..||:|:....|
Human   522 NAFKQRSHLAQHQKTHTGEKPYECNECGKAFSQTSNLTQHQRIH-TGEKPYKCTECGKAFSDSSS 585

  Fly   550 LRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            ...|||.|||:..|:|..|.:.|...:.|..| |::|...:|
Human   586 CAQHQRLHTGQRPYQCFECGKAFRRKLSLICH-QRSHTGEEP 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/60 (22%)
		COG5048	198..>508	CDD:227381	90/367 (25%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/73 (12%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF471	NP_065864.2	KRAB	14..73	CDD:214630	152/627 (24%)
		KRAB	14..53	CDD:279668
		COG5048	203..610	CDD:227381	118/415 (28%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	220..245	CDD:290200	11/24 (46%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..273	CDD:290200	9/24 (38%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-H2C2_2	276..301	CDD:290200	7/26 (27%)
		C2H2 Zn finger	292..312	CDD:275368	6/21 (29%)
		zf-H2C2_2	304..328	CDD:290200	7/23 (30%)
		C2H2 Zn finger	320..340	CDD:275368	2/19 (11%)
		zf-H2C2_2	332..357	CDD:290200	4/24 (17%)
		C2H2 Zn finger	348..366	CDD:275368	4/17 (24%)
		C2H2 Zn finger	377..397	CDD:275368	1/19 (5%)
		zf-H2C2_2	393..414	CDD:290200	11/20 (55%)
		C2H2 Zn finger	405..425	CDD:275368	5/20 (25%)
		zf-H2C2_2	420..442	CDD:290200	7/26 (27%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		zf-H2C2_2	445..470	CDD:290200	3/24 (13%)
		C2H2 Zn finger	461..481	CDD:275368	2/19 (11%)
		zf-H2C2_2	473..496	CDD:290200	3/22 (14%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		zf-H2C2_2	502..526	CDD:290200	7/24 (29%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		zf-H2C2_2	529..554	CDD:290200	13/24 (54%)
		C2H2 Zn finger	545..565	CDD:275368	10/19 (53%)
		zf-H2C2_2	557..581	CDD:290200	12/24 (50%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	601..621	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100