DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF490

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_065765.1	Gene:	ZNF490 / 57474	HGNCID:	23705	Length:	529	Species:	Homo sapiens

Alignment Length:	554	Identity:	139/554 - (25%)
Similarity:	228/554 - (41%)	Gaps:	96/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LACQEAQLKLSHIYDKIDASSLEDDEIG--QED---LEPAEEHQETETTKPTTTVSAETQPNNTA 137
            |..|.::.....|..:.|:.||||..:.  .|:   |:|.:.:...:..:.|
Human    38 LQMQNSEHHGQSIKTQTDSISLEDVAVNFTLEEWALLDPGQRNIYRDVMRAT------------- 89

  Fly   138 SDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITD------ESAP--------PQLTISYA 188
                  |.:...|.|..::::.|::.:.....:..|:.:      |..|        |.|..:..
Human    90 ------FKNLACIGEKWKDQDIEDEHKNQGRNLRSPMVEALCENKEDCPCGKSTSQIPDLNTNLE 148

  Fly   189 CKFCLRP------QENYQLQQLLLEHI--------NASHD-PEQPYNCPECEARFQDAASRTVHL 238
            ....|:|      .|.:..|..|..|:        |..|: .|:|:.|.||...|..::|...|.
Human   149 TPTGLKPCDCSVCGEVFMHQVSLNRHMRSHTEQKPNECHEYGEKPHKCKECGKTFTRSSSIRTHE 213

  Fly   239 KSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQF 303
            :....||.:.|..|||.:....:.|:|:..:..||.:||..|.|.|....:|..|.|.|..::.:
Human   214 RIHTGEKPYECKECGKAFAFLFSFRNHIRIHTGETPYECKECGKAFRYLTALRRHEKNHTGEKPY 278

  Fly   304 KCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCA 368
            ||:.  |.:.||..:..:.||.||:|   .|...|..|||.|.....||.| .:.|.||||:.|.
Human   279 KCKQ--CGKAFIYYQPFLTHERTHTG---EKPYECKQCGKAFSCPTYLRSH-EKTHTGEKPFVCR 337

  Fly   369 NCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANN 433
            .|...|.|::.     |.:|.:..|.::...|..|.:.|.|......|......::|
Human   338 ECGRAFFSHSS-----LRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFGEKP-------- 389

  Fly   434 KRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIK 498
                           ::|..|.:.||..|.|:.|..||: .::.:.|..|.|.|..:...:.|.:
Human   390 ---------------YECKQCGKAFNSSSYLQLHERVHT-GEKTYECKECGKAFLYSTHFRIHER 438

  Fly   499 THEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYY 563
            ||.:|||..|..||:.|.....|.:|..||..: |..:|..||:|:....||::|:|.|||:..:
Human   439 THTREKPYECKQCGRVFIYFSHLRRHERSHTGV-KPCECKQCGKAFTCLNSLKVHKRIHTGERPF 502

  Fly   564 KCDLCQERFVTHIKLKTHMQKAHAASQPHSADQP 597
            :|..|.:.|       ::.:..|...:.||..:|
Human   503 QCRQCGKAF-------SYSKSLHVHERTHSRQKP 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	2/8 (25%)
		COG5048	198..>508	CDD:227381	88/318 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF490	NP_065765.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		3/14 (21%)
		KRAB	56..97	CDD:307490	9/59 (15%)
		C2H2 Zn finger	133..150	CDD:275368	2/16 (13%)
		C2H2 Zn finger	158..178	CDD:275368	4/19 (21%)
		COG5048	192..>505	CDD:227381	102/348 (29%)
		C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	6/21 (29%)
		C2H2 Zn finger	308..328	CDD:275368	8/20 (40%)
		C2H2 Zn finger	336..356	CDD:275368	6/24 (25%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		C2H2 Zn finger	504..524	CDD:275368	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100