DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF304

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001277247.1	Gene:	ZNF304 / 57343	HGNCID:	13505	Length:	706	Species:	Homo sapiens

Alignment Length:	600	Identity:	147/600 - (24%)
Similarity:	234/600 - (39%)	Gaps:	136/600 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PSEMAQIRLQFANWNLKISPNDG--LPQKICS------------------------DC------- 66
            |.||....|:..   |.::.:.|  |.||:|:                        :|
Human   137 PCEMCDPLLKDI---LHLAEHQGSHLTQKLCTRGLCRRRFSFSANFYQHQKQHNGENCFRGDDGG 198

  Fly    67 --FTKFCSINAF--RLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTV 127
              |.|.|:::..  ...|:|..:.|.      |:|.|...:.....:.|...           |.
Human   199 ASFVKSCTVHMLGRSFTCREEGMDLP------DSSGLFQHQTTYNRVSPCRR-----------TE 246

  Fly   128 SAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFC 192
            ..|:.|::::.                     .:.|..||.::.....||..      ::...|.
Human   247 CMESFPHSSSL---------------------RQHQGDYDGQMLFSCGDEGK------AFLDTFT 284

  Fly   193 LRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYG 257
            |...:             .:|...:|:.|..|...|::.::...|.|....|..|.|..|||.:.
Human   285 LLDSQ-------------MTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFI 336

  Fly   258 DRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ..|:|:.| :|:|: :..:.|:.|.|.|..:.:|..|.:.|..:|.:.|  |.|.:.:....||:
Human   337 HLHHLKMH-QKFHTGKRHYTCSECGKAFSRKDTLVQHQRVHTGERSYDC--SECGKAYSRSSHLV 398

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE 386
            .|:..|:|....|   |..|||.|....||..| .|.|.||:||:|:.|.:.|:..:    |::|
Human   399 QHQRIHTGERPYK---CNKCGKAFSRKDTLVQH-QRFHTGERPYECSECGKFFSQSS----HLIE 455

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            ..|.: |.....||:.|.:.||....||.|                 :||....|.      :.|
Human   456 HWRIH-TGARPYECIECGKFFSHNSSLIKH-----------------RRVHTGARS------YVC 496

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|..|..|.:|..:|:.. ||:.|..|.|.|.|...:..|.|.|..|:|..|..|||.|:
Human   497 SKCGKAFGCKDTLVQHQIIHTGA-RPYECSECGKAFSRKDTLVQHQKIHTGERPYECGECGKFFS 560

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ....|..|:..| ...|.::||.||:.:....||.||||.|||...|.|..|.:.:::...|..|
Human   561 HSSNLIVHQRIH-TGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQH 624

  Fly   582 MQKAHAASQPHSADQ 596
             :|.|..::|:...:
Human   625 -KKVHTGARPYECSE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	16/88 (18%)
		COG5048	198..>508	CDD:227381	86/310 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF304	NP_001277247.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	169..186	CDD:275368	0/16 (0%)
		C2H2 Zn finger	216..236	CDD:275368	6/25 (24%)
		C2H2 Zn finger	245..264	CDD:275368	4/39 (10%)
		C2H2 Zn finger	272..292	CDD:275368	4/38 (11%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		COG5048	325..680	CDD:227381	108/351 (31%)
		C2H2 Zn finger	328..348	CDD:275368	8/20 (40%)
		zf-H2C2_2	340..365	CDD:290200	8/25 (32%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		C2H2 Zn finger	384..404	CDD:275368	6/21 (29%)
		zf-H2C2_2	396..421	CDD:290200	11/27 (41%)
		C2H2 Zn finger	412..432	CDD:275368	9/20 (45%)
		zf-H2C2_2	425..449	CDD:290200	11/24 (46%)
		C2H2 Zn finger	440..460	CDD:275368	6/23 (26%)
		C2H2 Zn finger	468..488	CDD:275368	8/36 (22%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	537..561	CDD:290200	10/23 (43%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		zf-H2C2_2	564..589	CDD:290200	8/25 (32%)
		C2H2 Zn finger	580..600	CDD:275368	10/19 (53%)
		C2H2 Zn finger	608..628	CDD:275368	5/20 (25%)
		C2H2 Zn finger	636..656	CDD:275368	0/2 (0%)
		C2H2 Zn finger	664..684	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100