DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF286A

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001275571.1	Gene:	ZNF286A / 57335	HGNCID:	13501	Length:	564	Species:	Homo sapiens

Alignment Length:	501	Identity:	127/501 - (25%)
Similarity:	199/501 - (39%)	Gaps:	124/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 DLEPAEEHQETETTKPTTTVS-AETQPNNTASDPIEIF----------VDAV--------DIDEA 153
            :||..:|..:.|...|.::.| .||:|.:..|..::.|          :|.:        :::.|
Human   134 NLENGKEPLKLERKAPKSSYSDMETRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNLEAA 198

  Fly   154 EEEEEEEEQQQ---------------QYDEEVEEP--------------ITDESAPPQLTISYAC 189
            .|.|...|.||               ...||.:..              ||::..|......:..
Human   199 LECENWLENQQGNQERHLREMFTHMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFHTL 263

  Fly   190 KFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGK 254
            :..|:.:.|...:|       .::..::|:.|.:|...|...:....|.:....||.:.|..|||
Human   264 EKSLKQKSNLMKKQ-------RTYKEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNECGK 321

  Fly   255 KYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRH 319
            .:..|.||..| ::.|:...|||:.|:|.|....||..|.:.|..:|.::|..  |.:.|....|
Human   322 SFSHRANLTKH-QRTHTRILFECSECKKTFTESSSLATHQRIHVGERPYECNE--CGKGFNRSTH 383

  Fly   320 LMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHM 384
            |:.|:..|:|.   |...|..|.|.|||...|..| .|.|.|||||||..|.:.|:
Human   384 LVQHQLIHTGV---KPYECNECDKAFIHSSALIKH-QRTHTGEKPYKCQECGKAFS--------- 435

  Fly   385 LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG-- 447
               |..:||                                              |.:|.::|
Human   436 ---HCSSLT----------------------------------------------KHQRVHTGEK 451

  Fly   448 LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCG 512
            .::|..|.:.|:..:.|.:|..:|: .::|:.|..|.|.|.|:.:...|.:.|..:||..|..||
Human   452 PYECSECGKTFSQSTHLVQHQRIHT-GEKPYECNECGKTFSRSSNFAKHQRIHIGKKPYKCSECG 515

  Fly   513 KAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            |||.....|.||:.:| ..||.|:||.||:::....||..|||.||
Human   516 KAFIHSSALIQHQRTH-TGEKPFRCNECGKSFKCSSSLIRHQRVHT 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/311 (25%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF286A	NP_001275571.1	KRAB	88..141	CDD:214630	2/6 (33%)
		KRAB	88..123	CDD:279668
		COG5048	<265..400	CDD:227381	39/147 (27%)
		C2H2 Zn finger	288..308	CDD:275368	4/19 (21%)
		zf-H2C2_2	301..325	CDD:290200	7/23 (30%)
		C2H2 Zn finger	316..336	CDD:275368	8/20 (40%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..380	CDD:290200	8/26 (31%)
		C2H2 Zn finger	371..391	CDD:275368	6/21 (29%)
		zf-H2C2_2	383..406	CDD:290200	9/25 (36%)
		COG5048	<395..550	CDD:227381	59/215 (27%)
		zf-C2H2	397..419	CDD:278523	9/22 (41%)
		C2H2 Zn finger	399..419	CDD:275368	9/20 (45%)
		zf-H2C2_2	411..436	CDD:290200	13/37 (35%)
		C2H2 Zn finger	427..447	CDD:275368	8/77 (10%)
		zf-H2C2_2	439..464	CDD:290200	8/70 (11%)
		C2H2 Zn finger	455..475	CDD:275368	5/19 (26%)
		zf-H2C2_2	467..492	CDD:290200	8/25 (32%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		zf-H2C2_2	495..518	CDD:290200	8/22 (36%)
		C2H2 Zn finger	511..531	CDD:275368	9/19 (47%)
		zf-H2C2_2	523..548	CDD:290200	11/25 (44%)
		C2H2 Zn finger	539..559	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100