DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF630

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001032824.2	Gene:	ZNF630 / 57232	HGNCID:	28855	Length:	657	Species:	Homo sapiens

Alignment Length:	528	Identity:	139/528 - (26%)
Similarity:	208/528 - (39%)	Gaps:	86/528 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDID 151
            ||..:.|.|  |.|:......||  ...::......||........|...||..:
Human   171 LSQKFHKFD--SCENSLKSNSDL--LNYNRSYARKNPTKRFRCGRPPKYNASCSV---------- 221

  Fly   152 EAEEEEEEEEQQQQY-DEEVEEPITDESAPPQLTISYACKFCLRPQEN---------YQLQQLLL 206
             .|:|.......:.| |.:.|:.::.:.|..|..     ||..|.:.|         .:..||::
Human   222 -PEKEGFIHTGMEPYGDSQCEKVLSHKQAHVQYK-----KFQAREKPNVCSMCGKAFIKKSQLII 280

  Fly   207 EHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS 271
            .  ...|..|:||.|.:|...|.:.:...||.:....||.:.|...|:.:..:.....|...:..
Human   281 H--QRIHTGEKPYVCGDCRKAFSEKSHLIVHQRIHTGEKPYECTKYGRAFSRKSPFTVHQRVHTG 343

  Fly   272 ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSE 336
            |..:||..|.|.|..:..|..|.:.|..::.|:|  |.|.:.|....||..|:.||:|   :|..
Human   344 EKPYECFECPKAFSQKSHLIIHQRVHTREKPFEC--SECRKAFCEMSHLFIHQITHTG---KKPY 403

  Fly   337 HCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYA----EKRIHMLER---------- 387
            .|..|||||.....|..| .|.|.|||||||..|.:.|...:    .:|||..|:
Human   404 ECTECGKTFPRKTQLIIH-QRTHTGEKPYKCGECGKTFCQQSHLIGHQRIHTGEKPYVCTDCGKA 467

  Fly   388 --HRENLTAIERSE-------CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRER 443
              .:.:||..:|..       |..|.:.||.:..||.|......::|
Human   468 FSQKSHLTGHQRLHTGEKPYMCTECGKSFSQKSPLIIHQRIHTGEKP------------------ 514

  Fly   444 QYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVC 508
                 :|||.|.:.|:.||.|..|..||: .::|:.|..|.:.|.....:..|.:.|..|||..|
Human   515 -----YQCGECGKTFSQKSLLIIHLRVHT-GEKPYECTECGRAFSLKSHLILHQRGHTGEKPYEC 573

  Fly   509 DVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFV 573
            ..|||||..|..|..|:.:|. .||..:|...|..:.::..:..:||.|||:...:|..|.:.|.
Human   574 SECGKAFCGKSPLIIHQKTHP-REKTPECAESGMTFFWKSQMITYQRRHTGEKPSRCSDCGKAFC 637

  Fly   574 THIKLKTH 581
            .|:....|
Human   638 QHVYFTGH 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	139/528 (26%)
		COG5048	198..>508	CDD:227381	92/341 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	4/19 (21%)
		C2H2 Zn finger	565..582	CDD:275368	5/17 (29%)
ZNF630	NP_001032824.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	238..257	CDD:275368	4/23 (17%)
		C2H2 Zn finger	265..285	CDD:275368	2/21 (10%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..330	CDD:290200	6/24 (25%)
		C2H2 Zn finger	321..341	CDD:275368	3/19 (16%)
		COG5048	<329..578	CDD:227381	78/278 (28%)
		zf-H2C2_2	336..358	CDD:290200	7/21 (33%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	377..397	CDD:275368	7/21 (33%)
		zf-H2C2_2	389..412	CDD:290200	11/25 (44%)
		C2H2 Zn finger	405..425	CDD:275368	9/20 (45%)
		zf-H2C2_2	418..440	CDD:290200	12/22 (55%)
		C2H2 Zn finger	433..453	CDD:275368	4/19 (21%)
		zf-H2C2_2	449..470	CDD:290200	4/20 (20%)
		C2H2 Zn finger	461..481	CDD:275368	3/19 (16%)
		zf-H2C2_2	473..498	CDD:290200	6/24 (25%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..526	CDD:290200	9/46 (20%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		zf-H2C2_2	530..553	CDD:290200	7/23 (30%)
		C2H2 Zn finger	545..565	CDD:275368	4/19 (21%)
		zf-H2C2_2	557..580	CDD:290200	9/22 (41%)
		C2H2 Zn finger	573..593	CDD:275368	9/19 (47%)
		C2H2 Zn finger	601..620	CDD:275370	3/18 (17%)
		C2H2 Zn finger	629..646	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100