DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and zgc:173720

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001107078.1	Gene:	zgc:173720 / 566529	ZFINID:	ZDB-GENE-080218-21	Length:	320	Species:	Danio rerio

Alignment Length:	431	Identity:	105/431 - (24%)
Similarity:	154/431 - (35%)	Gaps:	123/431 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNC 221
            :||.|     |.::||..|.:                  ||:.|.|..|.|:
Zfish     5 KEESE-----DVKIEETFTVK------------------QEDLQEQTDLREN------------- 33

  Fly   222 PECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYT 286
               |.|.::..    |:|.......|..|:.               |...:|.|.|..|.:.|..
Zfish    34 ---EGRKEEEH----HVKIEEKNNLHTDGIL---------------KRTDKTRFTCTHCRRSFGR 76

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTL 351
            :..|..||..|..::.|.|  :.|.:.|....||..|...|:|.....   |..|||:|.....|
Zfish    77 KGYLKIHMMIHTGEKPFTC--TQCGKSFSCSSHLNLHMMIHTGEIPFT---CTQCGKSFRKSSHL 136

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHH 416
            :.|: ..|.||||:.|..|.:.|:..:.:..||         .|...|     :||:
Zfish   137 KKHM-MSHTGEKPFTCTQCGKSFSQSSSRNKHM---------RIHTGE-----KPFT-------- 178

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
                                              |..|.:.|:..|.|..|..:|: .::|..||
Zfish   179 ----------------------------------CTQCGKSFSQLSFLNHHMMIHT-GEKPFTCP 208

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|.|.::.:...|::.|..|||..|..|||:::....|.:|...| ..||.|.|..||:.:..
Zfish   209 QCGKSFSKSSNFNQHMRIHTGEKPFTCTQCGKSYSQSSHLNKHIRIH-TGEKPFTCTQCGKCFTC 272

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHA 587
            ..:|..|.|.|||:..:.|..|.:.|.....|..|| |.||
Zfish   273 ISNLNQHMRIHTGEKPFICTQCGKSFSQLTSLNYHM-KFHA 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	68/309 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	1/19 (5%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
zgc:173720	NP_001107078.1	C2H2 Zn finger	67..87	CDD:275368	6/19 (32%)
		zf-H2C2_2	79..104	CDD:290200	8/26 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/21 (29%)
		zf-C2H2	121..143	CDD:278523	7/25 (28%)
		C2H2 Zn finger	123..143	CDD:275368	7/20 (35%)
		zf-H2C2_2	135..160	CDD:290200	10/25 (40%)
		COG5048	<147..307	CDD:227381	52/217 (24%)
		C2H2 Zn finger	151..171	CDD:275368	5/28 (18%)
		zf-H2C2_2	163..188	CDD:290200	9/80 (11%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		zf-H2C2_2	192..215	CDD:290200	8/23 (35%)
		C2H2 Zn finger	207..227	CDD:275368	6/19 (32%)
		zf-H2C2_2	219..244	CDD:290200	9/24 (38%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		zf-H2C2_2	247..272	CDD:290200	9/25 (36%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:290200	9/24 (38%)
		C2H2 Zn finger	291..311	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910