DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp386

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001004066.1	Gene:	Zfp386 / 56220	MGIID:	1930708	Length:	626	Species:	Mus musculus

Alignment Length:	577	Identity:	126/577 - (21%)
Similarity:	212/577 - (36%)	Gaps:	167/577 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SDCFTKFCSINAFRLACQEAQLKLSH----------IYDKI--DASSLEDDEIGQEDLEPAEEHQ 116
            :|.|.:.|..|     |:..|....|          :.|::  .:|:..|.|:  .:..|..:..
Mouse   162 TDTFDEPCVYN-----CKYPQEIFQHDLTLKESWEDLIDRLIFHSSNFIDKEL--RNRGPISKSD 219

  Fly   117 ETETTKPTTTVSAET-------QPNNT------ASDPI--------------------------- 141
            :.|::.|...:....       |.:||      |:||:
Mouse   220 QVESSYPGRAILFSQQIPVSCGQKHNTNDCGLPATDPLLHSQNLDTDIWETPYMYKEISKGFSSG 284

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENY--QLQQL 204
            .:.....|:...|:..:.::.|..:|..:.......:.|.:|   :.|       :|:  |..:|
Mouse   285 SLLNSCNDVVILEKSGQRDKVQNDFDHCLSPNNHQCNLPKKL---FNC-------DNFFTQCSKL 339

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKY 269
            .::..|...|  ..|...:|:..|....:.| ..|..|.:|.:.|..|||.:....:.|.|...:
Mouse   340 TIQQCNYIQD--NHYKSIDCDTMFNKTLNVT-RRKIQHSKKSYKCNECGKAFKYCSSYRKHSIIH 401

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            ..|..::|.||.|.|....||..|.:.|..::.::|..
Mouse   402 TGEKPYKCKLCGKSFTQCASLKKHQRIHTGEKPYRCEE--------------------------- 439

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE 399
                  ||::|.|...|..| .|.|.|||||||..|.:.|...:.     |::|:
Mouse   440 ------CGRSFNHYSILGQH-QRIHTGEKPYKCKQCGKSFTQCSS-----LQKHQ---------- 482

  Fly   400 CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSAL 464
                         :||                        ..|:.|    :|..|.:.|...|.|
Mouse   483 -------------VIH------------------------TGEKPY----RCAECGKSFTQNSTL 506

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            .:|..:|: .::|:.|..|.|.|.:...::.|.:.|..|||..|:|||:||..:...|:|:..|
Mouse   507 SQHQRIHT-GEKPYKCEECGKAFTQCSSLRKHQRIHTGEKPYKCEVCGRAFNCRSSFTKHKRIH- 569

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            ..||.:||..|.:|::...:|..|||.|||:..|||:.|.:.|.....|:.| ::.|
Mouse   570 TGEKPYKCKDCDKAFIHCTNLIQHQRIHTGEKPYKCNECGKSFSQCSNLRKH-ERIH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	6/22 (27%)
		COG5048	198..>508	CDD:227381	69/311 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	1/21 (5%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp386	NP_001004066.1	KRAB	6..>46	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	356..373	CDD:275368	4/17 (24%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	393..418	CDD:290200	8/24 (33%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	421..446	CDD:290200	8/57 (14%)
		C2H2 Zn finger	437..457	CDD:275368	8/53 (15%)
		zf-H2C2_2	452..474	CDD:290200	12/22 (55%)
		COG5048	<461..621	CDD:227381	58/217 (27%)
		C2H2 Zn finger	465..485	CDD:275368	5/47 (11%)
		zf-H2C2_2	477..502	CDD:290200	9/80 (11%)
		C2H2 Zn finger	493..513	CDD:275368	6/19 (32%)
		zf-H2C2_2	506..530	CDD:290200	8/24 (33%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		zf-H2C2_2	533..558	CDD:290200	11/24 (46%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		zf-H2C2_2	561..584	CDD:290200	8/23 (35%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..614	CDD:290200	12/24 (50%)
		C2H2 Zn finger	605..625	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100