DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	481	Identity:	134/481 - (27%)
Similarity:	210/481 - (43%)	Gaps:	52/481 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 ETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPP 181
            ||......|....|.|.::.....:|  .|.::|.:.::::..:::..:|.|..|.|....|...
Human   310 ETGDVCEDTFKELEGQTSDEEGSRLE--NDFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVE 372

  Fly   182 QLTI-----SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSS 241
            ...:     ||.|..|   .:.:.....|:.| ...|..|:||.|.||...|:..:...|||::.
Human   373 HEGVLKGQKSYRCDEC---GKAFNRSSHLIGH-QRIHTGEKPYECNECGKTFRQTSQLIVHLRTH 433

  Fly   242 HVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR 306
            ..||.:.|..|||.|....:|..|...::.|..::|..|.|.|.....|..|.:.|..::.::|.
Human   434 TGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQRTHTGEKPYECN 498

  Fly   307 HSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCT 371
            .  |...||..:.|..|:..|:|   :|...|..||:.|...:.|..| .|.|.|||||:|:.|.
Human   499 E--CGEAFIRSKSLARHQVLHTG---KKPYKCNECGRAFCSNRNLIDH-QRIHTGEKPYECSECG 557

  Fly   372 EVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRV 436
            :.|:     |...|.||:...|..:..:|..|.:.|:....||.|
Human   558 KAFS-----RSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLIEH-------------------- 597

  Fly   437 LQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKT 499
                 ||.::|  .|:|..|.:.|.:...|.||..:|: .::|:.|..|.|.|.:...:..|.:.
Human   598 -----ERIHTGEKPFECSECGKAFGLSKCLIRHQRLHT-GEKPYKCNECGKSFNQNSHLIIHQRI 656

  Fly   500 HEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            |..|||..|:.|||.|:....|..|:.:| ..||.:|||.||:|:.....|.:|||.|||:..|:
Human   657 HTGEKPYECNECGKVFSYSSSLMVHQRTH-TGEKPYKCNDCGKAFSDSSQLIVHQRVHTGEKPYE 720

  Fly   565 CDLCQERFVTHIKLKTHMQKAHAASQ 590
            |..|.:.| :......|.|:.|...:
Human   721 CSECGKAF-SQRSTFNHHQRTHTGEK 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	87/311 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708
		SCAN	51..138	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215
		KRAB_A-box	231..270	CDD:143639
		COG5048	380..738	CDD:227381	119/400 (30%)
		zf-C2H2	383..405	CDD:278523	5/25 (20%)
		C2H2 Zn finger	385..405	CDD:275368	4/23 (17%)
		zf-H2C2_2	401..422	CDD:290200	9/21 (43%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..450	CDD:290200	10/23 (43%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..478	CDD:290200	7/24 (29%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		zf-H2C2_2	482..506	CDD:290200	6/25 (24%)
		C2H2 Zn finger	497..517	CDD:275368	6/21 (29%)
		zf-H2C2_2	509..532	CDD:290200	8/25 (32%)
		C2H2 Zn finger	525..545	CDD:275368	7/20 (35%)
		zf-H2C2_2	537..562	CDD:290200	12/30 (40%)
		C2H2 Zn finger	553..573	CDD:275368	7/24 (29%)
		zf-H2C2_2	566..590	CDD:290200	7/23 (30%)
		C2H2 Zn finger	581..601	CDD:275368	8/44 (18%)
		zf-H2C2_2	594..616	CDD:290200	9/46 (20%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	622..646	CDD:290200	9/24 (38%)
		C2H2 Zn finger	637..657	CDD:275368	5/19 (26%)
		zf-H2C2_2	649..674	CDD:290200	10/24 (42%)
		C2H2 Zn finger	665..685	CDD:275368	7/19 (37%)
		zf-H2C2_2	677..701	CDD:290200	11/24 (46%)
		C2H2 Zn finger	693..713	CDD:275368	9/19 (47%)
		zf-H2C2_2	706..730	CDD:290200	11/24 (46%)
		C2H2 Zn finger	721..741	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754		3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100