DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF415

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_024307363.1	Gene:	ZNF415 / 55786	HGNCID:	20636	Length:	678	Species:	Homo sapiens

Alignment Length:	656	Identity:	160/656 - (24%)
Similarity:	243/656 - (37%)	Gaps:	171/656 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HHPNCWPSEMAQIRL--QFANWN-LKISPNDG----LPQKICSDCFTKFCSINAFRLACQEAQLK 86
            |....|..| :|:|:  :...|. :|....||    ||:..|:...:..|::
Human    99 HRKEPWTIE-SQVRVARKPKGWEWIKGVKTDGVSLLLPRLECNGAISAHCNL------------- 149

  Fly    87 LSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDID 151
              .:.|..|:.:......|..||.             ...|..|..|.. ..:|.|:| ..|.::
Human   150 --RLPDSNDSPASASRVAGITDLS-------------RNCVIKELAPQQ-EGNPGEVF-HTVTLE 197

  Fly   152 EAEEEEEEE-------------EQQQQYDEEVEEPITDESAPPQ-LTISYACKFCLRPQEN---- 198
            :.|:.:.||             :.|.:.||.....:|  :||.: ||       |.|.|.:
Human   198 QHEKHDIEEFCFREIKKKIHDFDCQWRDDERNCNKVT--TAPKENLT-------CRRDQRDRRGI 253

  Fly   199 -----------------YQLQQLLLE-------HI------NASHDP------------------ 215
                             ::|||...|       |:      .:|..|
Human   254 GNKSIKHQLGLSFLPHPHELQQFQAEGKIYECNHVEKSVNHGSSVSPPQIISSTIKTHVSNKYGT 318

  Fly   216 -----------------EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLR 263
                             |:||...||:......:..||...|...||.:.|.:|||.:..:.||.
Human   319 DFICSSLLTQEQKSCIREKPYRYIECDKALNHGSHMTVRQVSHSGEKGYKCDLCGKVFSQKSNLA 383

  Fly   264 HHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHS 328
            .|...:..|..::|..|::.|.....|..|.:.|..::.:||..  |:::|.....|..|:.||.
Human   384 RHWRVHTGEKPYKCNECDRSFSRNSCLALHRRVHTGEKPYKCYE--CDKVFSRNSCLALHQKTHI 446

  Fly   329 GTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ--HGGEKPYKCANCTEVFASYAEKRIHMLERHREN 391
            |   .|...|..|||.|....||..|   |  |.|:|||||..|.:||:..:.     |..|:..
Human   447 G---EKPYTCKECGKAFSVRSTLTNH---QVIHSGKKPYKCNECGKVFSQTSS-----LATHQRI 500

  Fly   392 LTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
            .|..:..:|..|.:.||....|..|......::|                       ::|..|.:
Human   501 HTGEKPYKCNECGKVFSQTSSLARHWRIHTGEKP-----------------------YKCNECGK 542

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|:..|.|..|..||: .::|:.|..|.|.|....::..|...|..|||..|:.|||.|::...|
Human   543 VFSYNSHLASHRRVHT-GEKPYKCNECGKAFSVHSNLTTHQVIHTGEKPYKCNQCGKGFSVHSSL 606

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            |.|::.| ..||.:|||.||:::....:|..||..||||..|||..|.:.|.....|..| |..|
Human   607 TTHQVIH-TGEKPYKCNECGKSFSVRPNLTRHQIIHTGKKPYKCSDCGKSFSVRPNLFRH-QIIH 669

  Fly   587 AASQPH 592
            ...:|:
Human   670 TKEKPY 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/64 (20%)
		COG5048	198..>508	CDD:227381	88/380 (23%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/22 (41%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF415	XP_024307363.1	KRAB	51..91	CDD:307490
		COG5048	<235..497	CDD:227381	68/281 (24%)
		C2H2 Zn finger	343..361	CDD:275368	4/17 (24%)
		COG5048	367..>662	CDD:227381	99/332 (30%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	5/21 (24%)
		C2H2 Zn finger	453..473	CDD:275368	9/22 (41%)
		C2H2 Zn finger	481..501	CDD:275368	6/24 (25%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..585	CDD:275368	5/19 (26%)
		C2H2 Zn finger	593..613	CDD:275368	8/19 (42%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		C2H2 Zn finger	649..669	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100