DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF701

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001166126.1	Gene:	ZNF701 / 55762	HGNCID:	25597	Length:	531	Species:	Homo sapiens

Alignment Length:	387	Identity:	109/387 - (28%)
Similarity:	155/387 - (40%)	Gaps:	87/387 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SHDPEQPYNCPE------CEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHN------LRH 264
            ||.||.....||      .|....||.|.:...:.|...|..    ...||  |:|      |..
Human   212 SHLPEVHIFHPEGKIGNQVEKAINDAFSVSASQRISCRPKTR----ISNKY--RNNFLQSSLLTQ 270

  Fly   265 HVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSG 329
            ..|.:..|..|:.....|.|.....|..|...|..|:|:||  ..|.:.|..:|:|.||.. |:|
Human   271 KREVHTREKSFQRNESGKAFNGSSLLKKHQIIHLGDKQYKC--DVCGKDFHQKRYLACHRC-HTG 332

  Fly   330 TSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTA 394
            .:...   |..|||||.|...|..| ...|.|||||||..|.:|
Human   333 ENPYT---CNECGKTFSHNSALLVH-KAIHTGEKPYKCNECGKV--------------------- 372

  Fly   395 IERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFN 459
                        |:.:.:|..|......::|                       ::|..|.:.|:
Human   373 ------------FNQQSNLARHHRVHTGEKP-----------------------YKCEECDKVFS 402

  Fly   460 MKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH 524
            .||.||||..:|: .::|:.|..|.|.|:|...:..|...|..|||..|:.|||.|.....|..|
Human   403 RKSHLERHRRIHT-GEKPYKCKVCDKAFRRDSHLAQHTVIHTGEKPYKCNECGKTFVQNSSLVMH 466

  Fly   525 RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            ::.| ..||.:|||.||:.:..:.:|..|:|.|||:..|||:.|.:.|    ..|:::::.|
Human   467 KVIH-TGEKRYKCNECGKVFNHKSNLACHRRLHTGEKPYKCNECGKVF----NRKSNLERHH 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	81/307 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/25 (24%)
		C2H2 Zn finger	249..269	CDD:275368	6/25 (24%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF701	NP_001166126.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		KRAB	74..>114	CDD:214630
		KRAB	74..113	CDD:279668
		C2H2 Zn finger	283..303	CDD:275368	4/19 (21%)
		zf-H2C2_2	296..320	CDD:290200	9/25 (36%)
		C2H2 Zn finger	311..330	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..358	CDD:275368	9/20 (45%)
		zf-H2C2_2	350..375	CDD:290200	13/58 (22%)
		C2H2 Zn finger	366..386	CDD:275368	6/52 (12%)
		zf-H2C2_2	378..403	CDD:290200	6/47 (13%)
		COG5048	<390..527	CDD:227381	50/163 (31%)
		C2H2 Zn finger	394..414	CDD:275368	9/19 (47%)
		zf-H2C2_2	406..431	CDD:290200	10/25 (40%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..459	CDD:290200	10/24 (42%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	10/25 (40%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	11/28 (39%)
		C2H2 Zn finger	506..526	CDD:275368	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100