DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF334

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001340754.1	Gene:	ZNF334 / 55713	HGNCID:	15806	Length:	703	Species:	Homo sapiens

Alignment Length:	403	Identity:	125/403 - (31%)
Similarity:	189/403 - (46%)	Gaps:	46/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACG 250
            ||.|..|   .:.:..:..|.||.. ||..|:||.|.||...|...:...||.::...||.:.|.
Human   343 SYECNEC---GKTFFRKSALAEHFR-SHTGEKPYECKECGNAFSKKSYLVVHQRTHRGEKPNECK 403

  Fly   251 VCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI 315
            .|||.:..:..|..|...:..|..:||:.|||.|:.:.:||.|.:.|..::.::|  |.|.:...
Human   404 ECGKTFFCQSALTAHQRIHTGEKPYECSECEKTFFCQSALNVHRRSHTGEKPYEC--SQCGKFLC 466

  Fly   316 SQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEK 380
            ::..|:.|:.||.|   :||..|..|||.|.|..||..| .|.|.|||......|..:
Human   467 TKSALIAHQITHRG---KKSYECNECGKFFCHKSTLTIH-QRTHTGEKHGVFNKCGRI------- 520

  Fly   381 RIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKR--ER 443
                         :|.:|.|..|:: .:::.:|  :..:||    |..:..|:..::.|:.  ||
Human   521 -------------SIVKSNCSQCKR-MNTKENL--YECSEH----GHAVSKNSHLIVHQRTIWER 565

  Fly   444 QYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVC 508
            .|    :|..|.:.:..||||..|...|:.: ||:.|..|.|.|.:......|.:||..|||..|
Human   566 PY----ECNECGRTYCRKSALTHHQRTHTGQ-RPYECNECGKTFCQKFSFVEHQRTHTGEKPYEC 625

  Fly   509 DVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFV 573
            :.|||:|..|.....||..| ..||.::||.||:.|....:|..||:.|||:..|:|:.|::.|.
Human   626 NECGKSFCHKSAFRVHRRIH-TGEKPYECNQCGKTYRRLWTLTEHQKIHTGEKPYECNKCEKTFR 689

  Fly   574 THIKLKTHMQKAH 586
            .......| ||:|
Human   690 HKSNFLLH-QKSH 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/311 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF334	NP_001340754.1	KRAB_A-box	<73..93	CDD:322003
		C2H2 Zn finger	235..254	CDD:275368
		C2H2 Zn finger	262..282	CDD:275368
		C2H2 Zn finger	290..310	CDD:275368
		C2H2 Zn finger	318..338	CDD:275368
		COG5048	342..697	CDD:227381	121/396 (31%)
		C2H2 Zn finger	346..366	CDD:275368	5/23 (22%)
		C2H2 Zn finger	374..394	CDD:275368	6/19 (32%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		C2H2 Zn finger	430..450	CDD:275368	8/19 (42%)
		C2H2 Zn finger	458..478	CDD:275368	5/21 (24%)
		C2H2 Zn finger	486..506	CDD:275368	10/20 (50%)
		C2H2 Zn finger	542..561	CDD:275368	5/22 (23%)
		C2H2 Zn finger	569..589	CDD:275368	7/19 (37%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	8/19 (42%)
		C2H2 Zn finger	653..673	CDD:275368	8/19 (42%)
		C2H2 Zn finger	681..701	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100