DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	529	Identity:	118/529 - (22%)
Similarity:	175/529 - (33%)	Gaps:	188/529 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CFTKFCSINAFRLACQEAQLKLSH-------------IYDKIDASS--------LEDDEI-GQE- 107
            |.|||.|            |:||:             .|::::|.|        :..|.: |||
Human   306 CRTKFKS------------LQLSYRKVRRGRVPEPCIFYEEMNALSGSWASAPPMASDAVPGQEG 358

  Fly   108 -DLEPAE-EHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEV 170
             |:|..| .||..|.|:                      |:...:|.|:.:|::.....|...::
Human   359 SDIEAGELNHQNGEPTE----------------------VEDGTVDGADRDEKDFRNPGQEVRKL 401

  Fly   171 EEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRT 235
            :.|:.   .|.:|...:.             .::..|::......|...|      :.....||.
Human   402 DLPVL---FPNRLGFEFK-------------NEIKKENLKWDDSEEVEIN------KALQRKSRG 444

  Fly   236 VH--------LKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNY 292
            |:        |:|....::.    |....|:........||. |...| ||
Human   445 VYWHSELQKGLESEPTSRRQ----CRNSPGESEEKTPSQEKM-SHQSF-CA-------------- 489

  Fly   293 HMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHS----GTSSRKSEHCGFCGKTFIHLKTLRW 353
                    |...|.|..|.:        .|.::.||    .....|...|..|||||.....|..
Human   490 --------RDKACTHILCGK--------NCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVR 538

  Fly   354 HIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMS 418
            | .|.|.||||:||:.|.:.|:            .|.||||                     |:.
Human   539 H-QRIHTGEKPHKCSECGKGFS------------ERSNLTA---------------------HLR 569

  Fly   419 AEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHC 483
            ....:||                       :|||.|.:.||..|:|..|...|: .::|:.|..|
Human   570 THTGERP-----------------------YQCGQCGKSFNQSSSLIVHQRTHT-GEKPYQCIVC 610

  Fly   484 SKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEK 548
            .|||..:.....|.:.|..|.|..|.||||.|......:.||.:| ..||.::|:.|.|.:....
Human   611 GKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTH-TGEKPYRCSHCERGFTKNS 674

  Fly   549 SLRLHQRTH 557
            :|..||..|
Human   675 ALTRHQTVH 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	6/20 (30%)
		COG5048	198..>508	CDD:227381	70/321 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/27 (15%)
		C2H2 Zn finger	249..269	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	305..327	CDD:275368	4/21 (19%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	1/19 (5%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395		15/69 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		5/34 (15%)
		COG5048	<455..668	CDD:227381	77/307 (25%)
		zf-C2H2	522..543	CDD:278523	9/21 (43%)
		C2H2 Zn finger	523..543	CDD:275368	9/20 (45%)
		zf-H2C2_2	535..559	CDD:290200	11/24 (46%)
		C2H2 Zn finger	551..571	CDD:275368	9/52 (17%)
		zf-H2C2_2	563..588	CDD:290200	12/68 (18%)
		C2H2 Zn finger	579..599	CDD:275368	8/19 (42%)
		zf-H2C2_2	591..616	CDD:290200	9/25 (36%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	10/20 (50%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
		zf-H2C2_2	647..671	CDD:290200	8/24 (33%)
		zf-C2H2	661..683	CDD:278523	6/21 (29%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910