DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and znf420

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001016394.1	Gene:	znf420 / 549148	XenbaseID:	XB-GENE-5724906	Length:	410	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	125/471 - (26%)
Similarity:	189/471 - (40%)	Gaps:	81/471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEE 159
            |..|||..| ...|.:.:....||...:|.::.::....|:    |.|...:|......:.|..:
Frog     7 DLPSLEMKE-SHNDEDNSRAASETSNGQPVSSRNSSEGSNS----PAETGSEAEGNLPGQSENTD 66

  Fly   160 EEQQQQYD--EEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCP 222
            .|..:..|  ::.:|.:|.|:....:     ||..|                       ..|.|.
Frog    67 SELLETPDLFDDDDESVTGETKKNDI-----CKKVL-----------------------AKYMCM 103

  Fly   223 ECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSET-DFECALCEKRFYT 286
            .|...|......|||.::...|:.::|.||||::....:|..|: :.|||. .|.|..|.|.|..
Frog   104 VCGKMFYRKPDYTVHQRTHTGERPYSCTVCGKRFTQSSSLARHL-RVHSEVKPFMCTDCGKSFSQ 167

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTL 351
            ...|..|.:.|..:|.:.|..  |.:.|....:|:.|:..|:|   .||.||..|||:|.....|
Frog   168 NSHLVTHQRIHTGERPYSCNE--CGKSFSGSSNLVKHKKVHAG---EKSWHCPGCGKSFTCSSQL 227

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFAS----YAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPD 412
            |.|: |.|..||||.|..|.:.|:|    ...:|:|..||         ...|..|.:.|:....
Frog   228 RTHL-RVHTNEKPYACEICGKCFSSSSNLVTHQRVHTGER---------PYSCTECGKRFTQSSS 282

  Fly   413 LIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRP 477
            |:.|.....:::                       ||.|..|.:.|:..|.|.:|...|:| :||
Frog   283 LVVHWRVHTVEK-----------------------LFTCSDCGKSFSHNSLLIKHQKTHTE-ERP 323

  Fly   478 HACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGR 542
            :.|..|.|.|..:..:..|.:.|.:|:|..|..|||.|..|..|.:|...|.. :|.:.|..||.
Frog   324 YVCMECGKGFTGSSALVRHQRVHTEERPYTCSECGKRFKDKSSLVRHSRVHSE-DKPYACASCGE 387

  Fly   543 AYLFEKSLRLHQRTHT 558
            .:....:|..|.||||
Frog   388 TFNDGSNLLEHLRTHT 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/314 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
znf420	NP_001016394.1	CobT	<8..>91	CDD:130712	18/87 (21%)
		C2H2 Zn finger	102..122	CDD:275368	6/19 (32%)
		zf-H2C2_2	118..139	CDD:372612	7/20 (35%)
		C2H2 Zn finger	130..150	CDD:275368	7/20 (35%)
		COG5048	<141..386	CDD:227381	82/285 (29%)
		C2H2 Zn finger	158..178	CDD:275368	6/19 (32%)
		C2H2 Zn finger	186..206	CDD:275368	5/21 (24%)
		C2H2 Zn finger	214..234	CDD:275368	9/20 (45%)
		C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100