DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and B020011L13Rik

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001359285.1	Gene:	B020011L13Rik / 547097	MGIID:	3588191	Length:	492	Species:	Mus musculus

Alignment Length:	464	Identity:	126/464 - (27%)
Similarity:	199/464 - (42%)	Gaps:	67/464 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 FVD-AVDIDEAEEEEEEEEQQQQYDEEVEEPI-----TDESAP---PQLTISYACKFCLRPQENY 199
            |:| |::..:.|.|..:..|:..|.:.:.|..     .|:.||   |:.|.|          .|.
Mouse    10 FMDVALEFSKEEWECLDSAQRALYRDVMLENYNNLVSVDQEAPDTLPERTQS----------PNP 64

  Fly   200 QLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRH 264
            :....|..|:.:       |.|.||...:...:|..||.:....:|.:.|..|||.:....||:.
Mouse    65 KAHCRLSTHVTS-------YKCIECGKSYTKLSSLKVHQRLHTGDKPYKCNECGKYFTKSSNLKV 122

  Fly   265 HVEKYHSETDFECALCEKRFYTRKS-LNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHS 328
            |...:..:..::...|.| |:|:.| |..|.:.|..|:.:||..  ||:.|....||..|...|:
Mouse   123 HHRLHTGDKPYKYNECGK-FFTQVSYLKVHKRIHTGDKPYKCNE--CEKSFFQYSHLKIHHRLHT 184

  Fly   329 GTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLT 393
            |....|   |..|||:|.....|:.| .|.|.|:|||||..|.:.|..|:..:||    ||.: |
Mouse   185 GDKPYK---CNECGKSFTQYSDLKVH-QRIHTGDKPYKCNECEKSFTRYSHLKIH----HRLH-T 240

  Fly   394 AIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRF 458
            ..:..:|..|.:.|:...||..|.......:|                       ::|..|.:.|
Mouse   241 GEKPYKCNECGKSFAQYSDLKVHQRIHTGDKP-----------------------YKCNDCGKSF 282

  Fly   459 NMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA-LKYVLT 522
            ...|.|:.|..:|: .|:|..|..|.:.:.:...:|.|.:.|..:||..|:..||:|. |..|..
Mouse   283 TKSSNLKVHQRIHT-GDKPCKCNDCGESYTKLSSLKVHQRLHTGDKPYKCNEYGKSFKHLSSVKI 346

  Fly   523 QHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHA 587
            .|||  ....|.:|||.||:::....:|::|.|.|||....||:...:.|.....|:.| |:.|.
Mouse   347 HHRL--HTGYKPYKCNECGKSFTKSSNLKVHHRLHTGDKPCKCNDYGKSFTKSSNLEVH-QRIHM 408

  Fly   588 ASQPHSADQ 596
            ..:.:..::
Mouse   409 GEKTYECNK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/310 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/20 (45%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
B020011L13Rik	NP_001359285.1	KRAB	7..48	CDD:366587	8/37 (22%)
		COG5048	54..477	CDD:227381	115/420 (27%)
		C2H2 Zn finger	79..99	CDD:275368	6/19 (32%)
		C2H2 Zn finger	107..127	CDD:275368	7/19 (37%)
		C2H2 Zn finger	136..155	CDD:275368	7/19 (37%)
		C2H2 Zn finger	163..183	CDD:275368	7/21 (33%)
		C2H2 Zn finger	191..211	CDD:275368	8/20 (40%)
		C2H2 Zn finger	219..239	CDD:275368	8/23 (35%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	303..323	CDD:275368	4/19 (21%)
		C2H2 Zn finger	331..351	CDD:275368	9/21 (43%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	5/20 (25%)
		C2H2 Zn finger	415..435	CDD:275368	0/3 (0%)
		C2H2 Zn finger	443..463	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100