DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp607a

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001019897.2	Gene:	Zfp607a / 545938	MGIID:	3584526	Length:	686	Species:	Mus musculus

Alignment Length:	633	Identity:	154/633 - (24%)
Similarity:	247/633 - (39%)	Gaps:	161/633 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QEDLEP-AEEHQETETTKPTTTVSAETQ---PNNTASDPIEIFVDAV------------------ 148
            :::.|| ....:||:...|...:..|.:   |.|...| |.:|...:
Mouse    68 EQEKEPWMAVKEETDRPSPDLELCYEAENMSPENQTYD-INLFKQRIKQFSKTFDLKICSFTSGP 131

  Fly   149 --DIDEAEEEEEEEEQQQQYDEEVEEPI-TDESAPPQLTISYACKFCLRPQENYQLQQLLLEHIN 210
              :..:..:..:|.:..|:...:.|.|. |.::.......:|.||.|   .:.:..:..|.:| .
Mouse   132 NYNTSKGLQSSQEGDDNQKITNKEEIPTHTCQTLAHNTEKAYECKEC---GKCFGCRSTLTQH-Q 192

  Fly   211 ASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDF 275
            :.|..|:||.|.||...|:.....|.|.||...|:...|..|||.:.....|::|...:..|..|
Mouse   193 SVHAGEKPYECEECGKAFRLPQQLTRHQKSHSGERPFECNECGKAFHLPDLLKYHKVIHTDEKPF 257

  Fly   276 ECALCEKRF---------------------------YTRKS-LNYHMKWHNPDRQFKCRHSGCER 312
            ||.:|.|.|                           :.|:| |..|.|.|:.:|.|:|:  .|.:
Mouse   258 ECEVCGKSFKRVSHLVEHRTIHAGVKPYECSECAKAFKRRSYLMQHQKIHSGERPFQCK--DCGK 320

  Fly   313 LFISQRHLMCHEATHSGTSSRKSEHCG-------------------------FCGKTF------- 345
            .||....|..|:..|:...|.:.:|||                         .|||.|
Mouse   321 SFIVLAQLTRHQNIHTEDKSFECKHCGKIFSCGSFLLRHQSIHTNEKPFECNVCGKAFRLQVYLS 385

  Fly   346 IHLKT----------LRWHIYRQ----------HGGEKPYKCANCTEVF---ASYAE-KRIHM-- 384
            .|.||          |....:|:          |...|||:|..|..:|   :|:.| :.||.
Mouse   386 EHRKTHTDERPFECKLCGSAFRRKDQLSEHQKIHTNVKPYQCKECGNLFRRKSSFIEHQSIHSEK 450

  Fly   385 -----------------LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGA----- 427
                             |.||:::.:.....||..|.:.|.....|.:|.:....|:|.|
Mouse   451 KPFNCKDCGKVFRLNTHLMRHQKSHSGERPFECKECGKAFHLPSQLTYHKTVHTNQKPFACEECG 515

  Fly   428 -------PIIANNKRVLQQKRERQYSGL--FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHC 483
                   .:|.:  ||:       ::||  ::||.|.:.||.:|.|::|..:||: :||..|..|
Mouse   516 KSFKHVSSLIEH--RVI-------HAGLKPYECGECGKAFNHRSNLKQHQKIHSD-ERPFECKDC 570

  Fly   484 SKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEK 548
            .|.|.....:..|...|..||...|:.||.:|.||..|.||:..|..: |.::|..||:.::...
Mouse   571 GKGFTVLAQLTRHQSIHTGEKSFECEQCGSSFRLKSQLNQHQRIHTDV-KPYQCKECGKGFVRGT 634

  Fly   549 SLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :||:|||.|||:..::|:.|.|.|..|.:...|. :.|...:|...::
Mouse   635 ALRIHQRIHTGEKPFQCNKCGEAFQYHYQFLAHF-RTHTGKKPSECEE 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	104/426 (24%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	9/47 (19%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	11/72 (15%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp607a	NP_001019897.2	KRAB	14..75	CDD:214630	2/6 (33%)
		C2H2 Zn finger	175..195	CDD:275368	5/23 (22%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		COG5048	227..572	CDD:227381	83/356 (23%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	6/21 (29%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	3/19 (16%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		C2H2 Zn finger	511..531	CDD:275368	3/28 (11%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		C2H2 Zn finger	595..615	CDD:275368	9/19 (47%)
		zf-H2C2_2	608..632	CDD:404364	8/24 (33%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		zf-H2C2_2	635..658	CDD:404364	11/22 (50%)
		C2H2 Zn finger	651..671	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100