DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp260

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_059060.1	Gene:	Zfp260 / 53982	RGDID:	621205	Length:	407	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	128/441 - (29%)
Similarity:	190/441 - (43%)	Gaps:	74/441 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 EPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTV 236
            |.:.||..|.:..  |.|..|   ::.:.|:|..:|| ..:|..|:...|..|...|..|:|.|.
  Rat    10 ELLHDEPDPGEKV--YECDEC---RKTFSLEQHFVEH-KKTHGGEKSPECTGCGEEFSKASSLTR 68

  Fly   237 HLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSE-------------------------TDFE 276
            ||:|....:.:.||.||:.:..|.|...| :|.|:|                         ..:.
  Rat    69 HLRSRSRRESYKCGNCGRTFSQRGNFLSH-QKQHAEERPSESKKTPVPMTTIVRNQRNAGNKPYA 132

  Fly   277 CALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFC 341
            |..|.|.|..:..|..|.|.|..::.|:|..  |.|.|..:::|:.|:..|||   :|...|..|
  Rat   133 CKECGKAFNGKSYLKEHEKIHTGEKPFECNQ--CGRAFSQKQYLIKHQNVHSG---KKPFKCNEC 192

  Fly   342 GKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQP 406
            ||.|...:.|..| .|.|.|||||:|..|.:.|...:.     |.||:.:.|..:...|..|.:.
  Rat   193 GKAFSQKENLIIH-QRIHTGEKPYECKGCGKAFIQKSS-----LIRHQRSHTGEKPYTCKECGKA 251

  Fly   407 FSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVH 471
            ||.:.:|..|......::|                       ::|..|...|..|..|.:|..:|
  Rat   252 FSGKSNLTEHEKIHIGEKP-----------------------YKCNECGTIFRQKQYLIKHHNIH 293

  Fly   472 SEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFK 536
            : .::|:.|..|.|.|.|...:..|::.|..:||..|.||||||.....||.|..|| ..||.:.
  Rat   294 T-GEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQSSSLTVHMRSH-TGEKPYG 356

  Fly   537 CNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF------VTHIKLKTH 581
            ||.||:|:....:|.||.|.|||:..|:|..|.:.|      :.|.::..|
  Rat   357 CNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQRIHIH 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/334 (27%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	5/23 (22%)
Zfp260	NP_059060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		4/10 (40%)
		COG5048	21..401	CDD:227381	122/422 (29%)
		C2H2 Zn finger	25..45	CDD:275368	6/23 (26%)
		C2H2 Zn finger	53..73	CDD:275368	8/19 (42%)
		C2H2 Zn finger	81..101	CDD:275368	8/20 (40%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		C2H2 Zn finger	161..181	CDD:275368	6/21 (29%)
		C2H2 Zn finger	189..209	CDD:275368	8/20 (40%)
		C2H2 Zn finger	217..237	CDD:275368	6/24 (25%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	10/19 (53%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..405	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100