DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp317

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038937835.1	Gene:	Zfp317 / 500950	RGDID:	1565419	Length:	663	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	227/506 - (44%)	Gaps:	56/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQ 163
            |.|..:.:::..|.::..|| |:|...::..|......|||.:.:  :|..:.|...:.....:.
  Rat   170 LNDSMMIRDNWSPGDKDWET-TSKIKWSILMEDIFGKEASDGVRL--EASHLLEKSSDFTHLFEV 231

  Fly   164 QQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARF 228
            ......:.:||    ..|.....|....|....:|   :..|.:|| :.:|..:.:.|.:|:..|
  Rat   232 LNIGRHLAQPI----GMPTSKRPYHHHTCGAAFKN---RIHLTQHI-SMYDGRKMHECHQCQKAF 288

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYH 293
            ..:||.|.|.:....||.:.|..|||.:.|...||.|...:..|..|:|:.|...|.|..:|..|
  Rat   289 TTSASLTRHCRIHTGEKPYECSSCGKAFNDPSALRSHTRTHLKEKPFDCSQCGNAFRTLSALKIH 353

  Fly   294 MKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ 358
            |:.|..:|.:||  ..|.:.:....||:.|:.||:|   .:...|..|||.|.|...|:.|: |.
  Rat   354 MRVHTGERPYKC--DECGKAYGRSCHLIAHKRTHTG---ERPYECQDCGKAFQHPSHLKEHV-RN 412

  Fly   359 HGGEKPYKCANCTEVFASYA----EKRIHMLE-------------------RHRENLTAIERSEC 400
            |.||||::|..|.:.|...:    .|:.||:|                   :|..:....:..||
  Rat   413 HTGEKPFECIQCGKAFRWKSNFNLHKKNHMVEKTYECKDCGKSFSDLLSRRKHMRSHIVKKPVEC 477

  Fly   401 MLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQK---RERQYSGLFQCGSCSQ 456
            ..|.:.|.::..|..||::...::|      |....|::.....:|   :||.|    :|.||.:
  Rat   478 HQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKAFSASSNLTAHRKIHTQERHY----ECSSCGK 538

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|....:..||.::|..|.|.. |..|.|.|:....:|.|:::|..|||..||.|||.|::...|
  Rat   539 VFGDYLSRRRHMSIHLVKKRVE-CRQCGKAFRNQSTLKTHMRSHTGEKPYECDHCGKGFSIGSNL 602

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF 572
            ..||..| ..||.::|.|||:|:....|||.|.:||.|::... .||.:.|
  Rat   603 NVHRRIH-TGEKPYECLVCGKAFSDHSSLRSHVKTHRGRSSLH-HLCGKGF 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	97/341 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	3/8 (38%)
Zfp317	XP_038937835.1	KRAB	60..100	CDD:396083
		C2H2 Zn finger	256..273	CDD:275368	5/20 (25%)
		COG5048	279..649	CDD:227381	118/382 (31%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		C2H2 Zn finger	365..385	CDD:275368	5/21 (24%)
		C2H2 Zn finger	393..413	CDD:275368	9/20 (45%)
		C2H2 Zn finger	421..441	CDD:275368	4/19 (21%)
		C2H2 Zn finger	449..469	CDD:275368	1/19 (5%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..525	CDD:275368	3/19 (16%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	617..637	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100