DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and RGD1565622

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_008762535.2	Gene:	RGD1565622 / 500582	RGDID:	1565622	Length:	510	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	127/501 - (25%)
Similarity:	213/501 - (42%)	Gaps:	78/501 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DEIGQEDLE-----PAEEHQETETTKPTTT---VSAETQPNNTASDPIEIFVDA--VDIDEAEEE 156
            |||.:..|:     |.:.|....:.:.:..   .:..|:..:...|.::...:.  :.::.....
  Rat    49 DEISKMTLDSTQSTPYKTHLRDPSLRSSNLKRHKAGNTREVHKYKDCVQFLNECAIIGVNSGIHI 113

  Fly   157 EEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNC 221
            |.:|.:..::|::                 :.||.          :.:|.::||.    :..:.|
  Rat   114 ENKEHKNTEFDKD-----------------FVCKH----------KVMLKQNING----KNLHQC 147

  Fly   222 PECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYT 286
            .|||..|.......:|.:....||.:.|..|.|.:|.:.:||.|...:..|..::|:.|:|.|..
  Rat   148 SECEKCFTKTRKLHLHRRIHTGEKPYKCSECDKCFGCKGSLRIHQRIHTGEKPYKCSECDKCFVQ 212

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTL 351
            :..|..|.:.|..::.:||  |.|::.|..|.|...|:..|:|   .|...|..|.|.||....|
  Rat   213 QSHLTVHQRIHTGEKPYKC--SECDKCFGQQSHRSIHQRIHTG---EKPYKCSQCDKHFIQESCL 272

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHH 416
            |.| .|.|.|||||||:.|.:.|......|.|| ..|    |..:..:|..|.:.|..:..|..|
  Rat   273 RRH-QRIHTGEKPYKCSECDKCFTVKLTLRSHM-RIH----TGEKPYKCSECDKCFGRKGSLRIH 331

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
            ......::|                       ::|..|.:.|..|.:|..|..:|: .::|:.|.
  Rat   332 QRIHTGEKP-----------------------YKCSECDKYFGRKGSLRIHQRIHT-GEKPYKCS 372

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|||.:...::.|.:.|..:||..|..|.|.||.::.|:.|:..| ..||.:||:.|.:.:..
  Rat   373 QCDKRFTQESCLRRHQRIHTGDKPYKCCQCDKYFAQEFYLSIHQRVH-TGEKPYKCSECEKCFTE 436

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            :.:||.|.|.|||:..|||..|.:.|.....|:.|| :.|...:|:
  Rat   437 KGTLRNHMRIHTGEKPYKCSECDKCFTEKGTLRNHM-RIHIGEKPY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
RGD1565622	XP_008762535.2	COG5048	135..504	CDD:227381	114/388 (29%)
		C2H2 Zn finger	147..167	CDD:275368	6/19 (32%)
		C2H2 Zn finger	175..195	CDD:275368	7/19 (37%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	7/21 (33%)
		C2H2 Zn finger	259..279	CDD:275368	9/20 (45%)
		C2H2 Zn finger	287..307	CDD:275368	6/20 (30%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	6/20 (30%)
		C2H2 Zn finger	483..503	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100