DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp133

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001019484.2	Gene:	Zfp133 / 499900	RGDID:	1566283	Length:	544	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	147/601 - (24%)
Similarity:	219/601 - (36%)	Gaps:	117/601 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CWPSEMA--QIRLQFA--NWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDK 93
            ||...||  .:.:.|:  .|:|.......|.:::..:.::...|            |.:.....|
  Rat    16 CWKVHMAFRDVAVDFSQEEWSLLSPAQRSLYREVMLENYSNLVS------------LGIPFSKPK 68

  Fly    94 IDASSLEDDEIGQEDLE------PAEEHQE-----------TETTKPTTTVSAETQPNNTASDPI 141
            :.....:..|..:|:.:      ||:...|           |....|...|.:...|........
  Rat    69 LITQLEQGKETWREERKCPQVACPAQAKLELCPGHVCPPDLTNQKSPVQHVLSHHAPLIFTCLCA 133

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQ--LTISYACKFCLRPQENYQLQQL 204
            |..||..|..:...|::.:...:....:..|....|||.|.  .|...:.....||.:.
  Rat   134 ESHVDRGDSCQGALEKQHQASDKNSCRDKSEGGERESARPSSGRTKKGSLGALSRPPQG------ 192

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHA-------------------CG 250
                        ||.|.|.        ..|.|.:::|..:.:..                   |.
  Rat   193 ------------QPVNSPN--------GIRWVEMETSPAQARSTEEPEKLLKGIEILEFGTVNCE 237

  Fly   251 VCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI 315
            .||..:....||..|...:..|..:.|.:|||.|..:|||..|.|.|:.::...|:.  |.|.|.
  Rat   238 ECGLGFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCKE--CWRGFS 300

  Fly   316 SQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEK 380
            .:..|:.||.||||   .|...|..||:.|.....|..| .|.|.|||||.|..|.:.|:..:..
  Rat   301 RKSTLIIHERTHSG---EKPYMCSECGRGFSQKSNLIIH-QRTHSGEKPYVCRECGKGFSQKSAV 361

  Fly   381 RIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQY 445
            ..|. ..|.|..|.:    |..|...||...:.|.|......::|
  Rat   362 VRHE-STHLEEKTFL----CSDCGLGFSDRSNFISHQRTHSGEKP-------------------- 401

  Fly   446 SGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDV 510
               :.|..|.|.|..::.|..|...|| |::|:.|..|...|.:...:..|.:.|..|||.||.|
  Rat   402 ---YACKECGQCFRQRTTLVNHQRTHS-KEKPYVCGICGHSFSQNSTLISHRRMHTGEKPYVCGV 462

  Fly   511 CGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTH 575
            ||:.|:||..|.:|:..|.. ||...|..|||.:..:.:|..|||||:|:....|:.|...|...
  Rat   463 CGRGFSLKSHLNRHQNIHSG-EKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPIVCEECGRGFSQK 526

  Fly   576 IKLKTHMQKAHAASQP 591
            ..|..| |:.|:..:|
  Rat   527 SNLIAH-QRTHSGEKP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	10/57 (18%)
		COG5048	198..>508	CDD:227381	82/328 (25%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	10/19 (53%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp133	NP_001019484.2	KRAB	21..80	CDD:214630	10/70 (14%)
		KRAB	21..60	CDD:279668	7/50 (14%)
		COG5048	235..>530	CDD:227381	102/330 (31%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		zf-H2C2_2	248..272	CDD:290200	8/23 (35%)
		C2H2 Zn finger	264..284	CDD:275368	10/19 (53%)
		C2H2 Zn finger	292..312	CDD:275368	7/21 (33%)
		zf-H2C2_2	305..329	CDD:290200	12/26 (46%)
		zf-C2H2	318..340	CDD:278523	7/22 (32%)
		C2H2 Zn finger	320..340	CDD:275368	7/20 (35%)
		zf-H2C2_2	332..357	CDD:290200	12/25 (48%)
		C2H2 Zn finger	348..368	CDD:275368	4/20 (20%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..413	CDD:290200	7/47 (15%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		zf-H2C2_2	417..441	CDD:290200	9/24 (38%)
		C2H2 Zn finger	432..452	CDD:275368	4/19 (21%)
		zf-H2C2_2	445..468	CDD:290200	10/22 (45%)
		C2H2 Zn finger	460..480	CDD:275368	9/19 (47%)
		zf-H2C2_2	472..497	CDD:290200	9/25 (36%)
		zf-C2H2	487..508	CDD:278523	8/20 (40%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		zf-H2C2_2	500..525	CDD:290200	10/24 (42%)
		C2H2 Zn finger	516..536	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000