DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp286a

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001178850.1	Gene:	Zfp286a / 497923	RGDID:	1561950	Length:	520	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	126/496 - (25%)
Similarity:	198/496 - (39%)	Gaps:	120/496 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 DLEPAEEHQETETTKPTTTVS-AETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVE 171
            |.|..:|..:.|...|..:.| .||:|.:..|..:        :|..:||.::..|:..:|..||
  Rat    96 DSEDGKELLKLERKSPKCSDSDVETRPESKESTSV--------LDFPKEESDKRTQKTAFDPHVE 152

  Fly   172 EPI-----------TDESAPPQLTI------------------SYACKFCLRPQEN--------Y 199
            ..:           ..|..|.|::.                  :::.|.||...:.        :
  Rat   153 TALECEHWLEPQQGNREKHPRQVSTHPNSLPEEGDSECDVYWRNFSQKPCLMTDDRDLEGSCDFH 217

  Fly   200 QLQQLLLEHI-----NASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDR 259
            .|::.|.:..     ...:..::|:.|.:|...|...:....|.:....||.::|..|||.:..|
  Rat   218 TLEERLKQKSKFMKKQRPYKDKKPHKCDDCGELFTYHSVLIRHQRVHTGEKPYSCSECGKSFSHR 282

  Fly   260 HNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHE 324
            .||..| ::.|:...|||..|:|.|....:|..|.:.|..:|.::|  ..|.:.|....||..|:
  Rat   283 ANLTKH-QRTHTRVLFECGECKKTFIESSALAVHQRIHIGERPYEC--GECGKGFNRSTHLAQHQ 344

  Fly   325 ATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHR 389
            ..|:|.   |...|..|.|.|||...|..| .|.|.|||||||..|.:.|:            |.
  Rat   345 LIHTGV---KPYECNECDKAFIHSSALIKH-QRTHTGEKPYKCQECGKAFS------------HC 393

  Fly   390 ENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCG 452
            .:||                                              |.:|.::|  .::|.
  Rat   394 SSLT----------------------------------------------KHQRVHTGEKPYECS 412

  Fly   453 SCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFAL 517
            .|.:.|:..:.|.:|..:|: .::|:.|..|.|.|.|:.:...|.:.|..:||..|..|||||..
  Rat   413 ECGKTFSQSTHLVQHQRIHT-GEKPYECHECGKTFSRSSNFAKHQRIHVGKKPYKCGECGKAFIH 476

  Fly   518 KYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            ...|.||:.:| ..||.|:||.||:::....||..||||||
  Rat   477 SSALIQHQRTH-TGEKPFRCNECGKSFKCSSSLIRHQRTHT 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	78/324 (24%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp286a	NP_001178850.1	KRAB	50..>94	CDD:214630
		KRAB	50..85	CDD:279668
		COG5048	<240..422	CDD:227381	63/246 (26%)
		C2H2 Zn finger	244..264	CDD:275368	4/19 (21%)
		zf-H2C2_2	257..281	CDD:290200	7/23 (30%)
		C2H2 Zn finger	272..292	CDD:275368	8/20 (40%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		zf-H2C2_2	311..336	CDD:290200	7/26 (27%)
		C2H2 Zn finger	327..347	CDD:275368	6/21 (29%)
		zf-H2C2_2	339..362	CDD:290200	9/25 (36%)
		COG5048	<351..506	CDD:227381	59/215 (27%)
		zf-C2H2	353..375	CDD:278523	9/22 (41%)
		C2H2 Zn finger	355..375	CDD:275368	9/20 (45%)
		zf-H2C2_2	367..392	CDD:290200	13/37 (35%)
		C2H2 Zn finger	383..403	CDD:275368	8/77 (10%)
		zf-H2C2_2	395..420	CDD:290200	8/70 (11%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-H2C2_2	423..448	CDD:290200	8/25 (32%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-H2C2_2	451..474	CDD:290200	8/22 (36%)
		zf-C2H2	465..487	CDD:278523	9/21 (43%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
		zf-H2C2_2	479..504	CDD:290200	11/25 (44%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100