DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp868

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001009538.1	Gene:	Zfp868 / 494340	RGDID:	1359299	Length:	423	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	123/479 - (25%)
Similarity:	175/479 - (36%)	Gaps:	116/479 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 VEEPITDESAPPQLTISYACKFCLRPQENYQLQQ---------LLLEHINASHDPEQPY------ 219
            :|.||...|.|.|..:|:........|:.:.|.:         ::||......|....:
  Rat     1 METPIVGLSRPDQGLVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTDTGYEWEDQKIE 65

  Fly   220 -NCPECEARFQDAASRTVHLKS-SHVEKQH------------------------ACGVCGKKYGD 258
             :|.:.|...:|..|.:.:.:. .|.|.:.                        .|.||.|.||.
  Rat    66 DHCEDPEINLRDIVSHSEYTREYEHEEYEEKPPDANFLTSVKGYVGAHTVNGPSECEVCLKSYGL 130

  Fly   259 RHNL--RHHVEKYHS-------ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
            .|..  .||..:|..       ...:||..|.|...:..||..|.|.|..:|.:||:.  |.:.|
  Rat   131 YHLTYNGHHSYEYKECVGSQPVRKSYECNQCGKTLSSYNSLQRHQKIHVEERPYKCQQ--CSKAF 193

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE 379
            .....|..||..|:|   .|...|..||..|..|..||.| .:.|.|||.|:|..|..||.|::.
  Rat   194 RCLNALQSHERIHTG---EKPFECNHCGTAFSRLTHLRLH-EKVHTGEKHYECKQCNIVFKSHSS 254

  Fly   380 KRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQ 444
                 ..||:                       ::|..:
  Rat   255 -----FHRHK-----------------------IMHGET-------------------------- 265

  Fly   445 YSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCD 509
               .:.|..|.:.|...|.|:.|...|: .::|:.|..|.|.|:....::.|.:||..|||..|.
  Rat   266 ---FYNCKECGKSFIYPSLLQMHERTHT-GEKPYECKLCGKSFRYHSSIRLHERTHTGEKPYECK 326

  Fly   510 VCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVT 574
            .|||||..:..|..|..|| ..||.::|..||:|:.....||||:|.|||:..|:|..|...|..
  Rat   327 HCGKAFTRQSYLQFHERSH-TGEKPYECKECGKAFTHRSYLRLHERRHTGEKPYQCVQCGRSFSR 390

  Fly   575 HIKLKTHMQKAHAASQPHSADQPL 598
            ....|.| |..||...|:...|.|
  Rat   391 QSSFKRH-QSVHAVENPYKCQQYL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/359 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/20 (20%)
		C2H2 Zn finger	249..269	CDD:275368	9/21 (43%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	1/19 (5%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp868	NP_001009538.1	KRAB	16..>58	CDD:214630	6/41 (15%)
		KRAB	16..53	CDD:279668	5/36 (14%)
		C2H2 Zn finger	158..178	CDD:275368	7/19 (37%)
		zf-H2C2_2	170..195	CDD:290200	10/26 (38%)
		C2H2 Zn finger	186..206	CDD:275368	6/21 (29%)
		zf-H2C2_2	198..223	CDD:290200	10/27 (37%)
		C2H2 Zn finger	214..234	CDD:275368	8/20 (40%)
		COG5048	<225..423	CDD:227381	70/250 (28%)
		C2H2 Zn finger	242..262	CDD:275368	7/47 (15%)
		C2H2 Zn finger	269..289	CDD:275368	6/19 (32%)
		zf-H2C2_2	282..306	CDD:290200	8/24 (33%)
		C2H2 Zn finger	297..317	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..334	CDD:290200	12/24 (50%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..362	CDD:290200	10/25 (40%)
		C2H2 Zn finger	353..373	CDD:275368	9/19 (47%)
		zf-H2C2_2	365..390	CDD:290200	12/24 (50%)
		C2H2 Zn finger	381..401	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100