DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp960

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001005358.2	Gene:	Zfp960 / 449000	MGIID:	3052731	Length:	546	Species:	Mus musculus

Alignment Length:	507	Identity:	142/507 - (28%)
Similarity:	224/507 - (44%)	Gaps:	79/507 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIE-IFVDAVDIDEAEEEEEEEEQQ 163
            |:|.| :||.|        .:.:||..:..: .|:||...|.| |..|........:..::....
Mouse    57 EEDNI-EEDCE--------NSGRPTRHLQRD-GPSNTGEKPFECIQYDGAFARNHHQLHKDTGSF 111

  Fly   164 QQY-DEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEAR 227
            ..| |.::..                     ||                 |..|:.|:..:|...
Mouse   112 MSYTDRQIHR---------------------RP-----------------HTEEKVYDGNQCGKT 138

  Fly   228 FQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNY 292
            |.......:...:...||.:.|..|||.:....||..|...:..|..::|..|.|.|....:|:.
Mouse   139 FSCHNHFEIRKGTYTGEKPYECNQCGKAFARHSNLLDHKRIHTGEKPYKCKQCGKDFTHHSTLHI 203

  Fly   293 HMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYR 357
            |.:.|..::.:||..  |    ::..||.||:.||:|   .|...|..|||||.:.|||:.| .|
Mouse   204 HKRIHTREKTYKCNQ--C----MTIAHLQCHKITHTG---EKPYACKKCGKTFAYHKTLQIH-ER 258

  Fly   358 QHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHL 422
            .|.|||.|:|..|.:.|..:...:||  ||..   |..:..||..|.:.|:...:|.:|.:....
Mouse   259 THTGEKLYQCNQCAKAFPYHRTLQIH--ERTH---TGEKPYECNQCGKAFACLRNLQNHKTTHTG 318

  Fly   423 QRP------GAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHA 479
            ::|      |.   |..:.|..|..||.::|  .|:|..|.:.|...|.|:||...|: .::|:.
Mouse   319 EKPYECNQCGR---AFRQYVYLQCHERIHTGEKPFECNQCGKAFARHSTLQRHKRTHT-GEKPYE 379

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.|...:.::.|.:||..|||..|:.||||||....|..|:.:| ..|:.::||.||:|:
Mouse   380 CNQCGKAFACPRYLQIHKRTHTGEKPYECNQCGKAFACHRYLQIHKRTH-TGERPYECNQCGKAF 443

  Fly   545 LFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ....:|::|:|||||:..|:|:.|.:.|.....|:.| ::.|...:|:..:|
Mouse   444 TCRSNLQIHKRTHTGERPYECNQCGKAFTCRSNLQIH-KRTHTGEKPYECNQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/317 (29%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	11/20 (55%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp960	NP_001005358.2	KRAB	13..>54	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	133..152	CDD:275368	2/18 (11%)
		COG5048	156..525	CDD:227381	117/360 (33%)
		C2H2 Zn finger	160..180	CDD:275368	7/19 (37%)
		zf-H2C2_2	172..197	CDD:290200	8/24 (33%)
		C2H2 Zn finger	188..208	CDD:275368	6/19 (32%)
		zf-H2C2_2	224..249	CDD:290200	14/27 (52%)
		C2H2 Zn finger	240..260	CDD:275368	11/20 (55%)
		C2H2 Zn finger	268..288	CDD:275368	7/21 (33%)
		zf-H2C2_2	281..305	CDD:290200	9/28 (32%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		zf-H2C2_2	308..333	CDD:290200	5/27 (19%)
		C2H2 Zn finger	324..344	CDD:275368	6/22 (27%)
		zf-H2C2_2	336..361	CDD:290200	8/24 (33%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	365..389	CDD:290200	9/24 (38%)
		C2H2 Zn finger	380..400	CDD:275368	5/19 (26%)
		zf-H2C2_2	392..417	CDD:290200	12/24 (50%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		zf-H2C2_2	420..445	CDD:290200	9/25 (36%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		zf-H2C2_2	448..473	CDD:290200	11/24 (46%)
		C2H2 Zn finger	464..484	CDD:275368	5/20 (25%)
		zf-H2C2_2	476..501	CDD:290200	5/20 (25%)
		C2H2 Zn finger	492..512	CDD:275368	1/3 (33%)
		zf-H2C2_2	505..529	CDD:290200
		C2H2 Zn finger	520..540	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100