DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Sry-beta

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	92/370 - (24%)
Similarity:	139/370 - (37%)	Gaps:	86/370 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEP 111
            |..|::.||..    .|.||....  .|..||....:|::          ..:.|..:|...:|.
  Fly    47 NQRLELLPNSA----ACRDCLEYL--FNYDRLVRNLSQVQ----------RQIADALLGCRQVEG 95

  Fly   112 AEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAE----EEEEEEE--QQQQYDEEV 170
            ..|      ||......|..|.      |....|.|..:.|.|    ||:|.||  :::..|||.
  Fly    96 KAE------TKQQAAKRARVQV------PAFKIVQATALKEPERQPGEEDECEEFMKEEMLDEEF 148

  Fly   171 EEPITDESAPPQ------LTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQ 229
            :....|:|.|..      .|....|..|   .|.:..|::|..||.|.       .|.:.|
  Fly   149 QFSEPDDSMPSSEEEFFTETTEIPCHIC---GEMFSSQEVLERHIKAD-------TCQKSE---- 199

  Fly   230 DAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHM 294
                            |..|.|||.|..|...|..|:..:..:|:.||..|:|:|..::::..||
  Fly   200 ----------------QATCNVCGLKVKDDEVLDLHMNLHEGKTELECRYCDKKFSHKRNVLRHM 248

  Fly   295 KWHNPDRQFKCRHSGCERLFIS---QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIY 356
            :.|...::::|...| ||..:|   ..|||.|:|..:...      |..|.:.|...:|.:.|:
  Fly   249 EVHWDKKKYQCDKCG-ERFSLSWLMYNHLMRHDAEENALI------CEVCHQQFKTKRTYKHHL- 305

  Fly   357 RQHGGEKP-YKCANCTEVFAS----YAEKRIHMLERHRENLTAIE 396
            |.|..::| |.|.:|.:.|..    ...||:|......|:..|.|
  Fly   306 RTHQTDRPRYPCPDCEKSFVDKYTLKVHKRVHQPVEKPESAEAKE 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/39 (28%)
		COG5048	198..>508	CDD:227381	53/207 (26%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	10/24 (42%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368
		C2H2 Zn finger	451..471	CDD:275368
		C2H2 Zn finger	480..500	CDD:275368
		C2H2 Zn finger	508..528	CDD:275368
		C2H2 Zn finger	537..557	CDD:275368
		C2H2 Zn finger	565..582	CDD:275368
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	8/19 (42%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	16/56 (29%)
		C2H2 Zn finger	288..303	CDD:275370	4/14 (29%)
		zf-C2H2	315..337	CDD:278523	6/21 (29%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4053
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.880