DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp975

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001008427.1	Gene:	Zfp975 / 434179	MGIID:	3648690	Length:	525	Species:	Mus musculus

Alignment Length:	540	Identity:	141/540 - (26%)
Similarity:	212/540 - (39%)	Gaps:	121/540 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 IDASSLEDDEIGQEDLEPAEE--HQETETTKPTTTVS--AETQPNNTASDPIEIF--------VD 146
            |:.....|...|:.:..||.|  ::.|:..|.....|  .:.:.|.|.....|:|        ..
Mouse    52 IEEHCQNDRRYGRHERSPAGEKPYEYTQWNKAFKYHSHLQKLERNQTGDKNSEVFQHSKVLACQS 116

  Fly   147 AVDIDEAEEEEEEEEQQQQYDEEV---------EEPITDESAPPQLTISYACKFC---------L 193
            .:.|:|.....|:..:..:.|:..         |...|.|..       |.|..|         |
Mouse   117 TLQINERTGTGEKPYKCNECDKAFLKLKYLRAHERTHTGEKL-------YECNQCGKAFVHPSYL 174

  Fly   194 RPQEN-------YQLQQ-----LLLEHINAS---HDPEQPYNCPECEARFQDAASRTVHLKSSHV 243
            |..|.       ||..|     .|..|:.:.   |...:||.|.:|...:...:....|.::...
Mouse   175 RMHERTHTGEKPYQCNQCGKAFALRSHLQSHKVVHTGVRPYICNQCNKAYPRQSCLRKHERTHTG 239

  Fly   244 EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHS 308
            ||.:.|.:|.|.|..:.|||.|...::....:.|.||:|.|..:.....|.|.|..::.:||..
Mouse   240 EKPYICNLCNKAYSHQSNLRIHERTHNGAKPYICNLCDKAFSQQSCFQIHEKTHTGEKPYKCNQ- 303

  Fly   309 GCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEV 373
             |::.|...|:|..||.||   :..|:..|..|||.|..|..||.| .|:|.|||||||..|.:.
Mouse   304 -CDKGFAQLRYLRAHERTH---TQEKTYKCNQCGKAFAQLTYLRVH-ERRHSGEKPYKCNECDKA 363

  Fly   374 FASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQ 438
            |......|:|
Mouse   364 FLQLKYLRLH------------------------------------------------------- 373

  Fly   439 QKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHE 501
               ||:::|  .::|..|.:.|...|.|..|...|: .::|:.|..|:|.|.:.:.::.|.:.|.
Mouse   374 ---ERRHTGEKPYKCNQCGKAFLHPSYLRMHERTHT-GEKPYQCNECNKAFLQLRYLRLHERRHS 434

  Fly   502 KEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCD 566
            .|||..|:.|||||.....|..|...|.. ||.::||.||:|:|....||:|:|||||:..|:|.
Mouse   435 GEKPYECNQCGKAFLRPNNLRMHERRHSG-EKPYECNQCGKAFLHPSYLRMHERTHTGEKPYECS 498

  Fly   567 LCQERFVTHIKLKTHMQKAH 586
            .|.:.|:....|:.| :|.|
Mouse   499 QCGKAFLQPHYLRKH-EKTH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	82/326 (25%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp975	NP_001008427.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	98..514	CDD:227381	129/489 (26%)
		C2H2 Zn finger	109..125	CDD:275368	2/15 (13%)
		C2H2 Zn finger	133..153	CDD:275368	2/19 (11%)
		zf-H2C2_2	145..170	CDD:290200	6/31 (19%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		zf-H2C2_2	173..197	CDD:290200	6/23 (26%)
		C2H2 Zn finger	189..209	CDD:275368	3/19 (16%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		C2H2 Zn finger	245..265	CDD:275368	8/19 (42%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..310	CDD:290200	7/25 (28%)
		C2H2 Zn finger	301..321	CDD:275368	7/21 (33%)
		zf-H2C2_2	313..338	CDD:290200	11/27 (41%)
		C2H2 Zn finger	329..349	CDD:275368	10/20 (50%)
		zf-H2C2_2	341..366	CDD:290200	14/25 (56%)
		C2H2 Zn finger	357..377	CDD:275368	7/77 (9%)
		zf-H2C2_2	369..394	CDD:290200	8/82 (10%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	8/25 (32%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		zf-H2C2_2	425..450	CDD:290200	11/24 (46%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	453..478	CDD:290200	10/25 (40%)
		C2H2 Zn finger	469..489	CDD:275368	10/19 (53%)
		zf-H2C2_2	481..506	CDD:290200	12/24 (50%)
		C2H2 Zn finger	497..517	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100