DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp141

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001296317.1	Gene:	Zfp141 / 434178	MGIID:	3584269	Length:	685	Species:	Mus musculus

Alignment Length:	620	Identity:	152/620 - (24%)
Similarity:	241/620 - (38%)	Gaps:	114/620 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAISMFVCDFEN--GSNNSHFLD--------------------LHHPNCWPSEMAQIRLQ-FANW 48
            |.:......:||  |..:.|:|.                    ||  |...|:..:|..| ..:|
Mouse   130 CNVDQHKTVYENPVGRESHHWLGISEYCHRYQEDNKGLTTDFALH--NNHNSQFTEISYQGNDSW 192

  Fly    49 NL---KISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLE 110
            |:   .::|::|.    .|:|..:.| .|..|......|...|.:|.:         :..||.|
Mouse   193 NIYKQDVTPSEGQ----ISNCSLENC-YNNDRCRGVSGQCTQSPLYQQ---------DYSQEKL- 242

  Fly   111 PAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEE-EEEEEEQQQQYDE----EV 170
                                    :|:|...:|..:..:..:..| :...|..:|:||:    .|
Mouse   243 ------------------------STSSQQYKIANECSNCSQCTEIKARREFNRQRYDKYSKVSV 283

  Fly   171 EEP------ITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQ 229
            |.|      :.|....|.|.:.....|      |:.|.   :...::||..|:|....|......
Mouse   284 ESPSIDRDKVNDIQRKPCLFMGSDKSF------NFYLN---MTQNDSSHTREKPQKYKEYRLEIT 339

  Fly   230 DAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHM 294
            ..:....|.:|...:|....|.|.:...|...|:   ......|..:...|.|.|........:.
Mouse   340 SPSKLVGHPRSFVQQKYRKSGKCSRSSSDLSRLK---MLQPGGTPCKSTECGKSFSQFSGYRENG 401

  Fly   295 KWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQH 359
            ..|..::.:||:.  |:|.|.:..:|..|:..|:|   .|...|..|||:|.|..:||.| :|.|
Mouse   402 TIHTGEKPYKCKI--CKRSFTTGSYLQAHQRIHTG---EKPYKCKECGKSFTHGYSLRIH-HRFH 460

  Fly   360 GGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQR 424
            .|||||||.:|...||..:..:.|    ||.: |..:..:|..|.:.|:.:.:...|.......|
Mouse   461 TGEKPYKCKDCGRSFAEGSSLKSH----HRIH-TGEKPYKCKECGKSFAKQSNFETHSRIHTGDR 520

  Fly   425 P------GAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
            |      |...   .:....:|..:.::|  .::|..|.:.|..:|.|:.|..:|: .::|:.|.
Mouse   521 PYKCTDCGKSF---TRSFCLRKHHKTHTGEKAYKCEECGKAFTQRSTLKTHYRIHT-GEKPYKCN 581

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|.|.....:|.|:|.|..|||..|..|||:||....|..|...| ..||.:||..||:::..
Mouse   582 ECGKSFTEGSTLKTHLKIHTGEKPYKCKECGKSFAEASTLKTHHRIH-TGEKPYKCTDCGKSFTQ 645

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            ...|:.|.|.|||:..|||..|.:.|.....|:.|
Mouse   646 SSHLQSHCRIHTGEKPYKCKECGKSFAKDSSLQKH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	22/105 (21%)
		COG5048	198..>508	CDD:227381	82/317 (26%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/17 (29%)
Zfp141	NP_001296317.1	KRAB	18..78	CDD:214630
		C2H2 Zn finger	385..404	CDD:275368	3/18 (17%)
		C2H2 Zn finger	412..432	CDD:275368	6/21 (29%)
		zf-H2C2_2	424..449	CDD:372612	10/27 (37%)
		C2H2 Zn finger	440..460	CDD:275368	10/20 (50%)
		COG5048	<445..685	CDD:227381	78/247 (32%)
		C2H2 Zn finger	468..488	CDD:275368	7/23 (30%)
		C2H2 Zn finger	496..516	CDD:275368	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	2/22 (9%)
		C2H2 Zn finger	552..572	CDD:275368	6/19 (32%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	8/19 (42%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		C2H2 Zn finger	664..684	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100