DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Rslcan18

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001242981.1	Gene:	Rslcan18 / 432770	MGIID:	5433745	Length:	460	Species:	Mus musculus

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	200/475 - (42%)	Gaps:	66/475 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAE-TQPNNTASDPI 141
            |.|::. .||.|.........::.|:      ||        |.:....||.: .:.:...|..:
Mouse    44 LNCEQV-YKLLHSRRTRRGKGMDRDD------EP--------TLEKGKAVSPQWPEKSRLLSASV 93

  Fly   142 EI--FVD-AVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLR-PQENYQLQ 202
            |:  |.| |:|....|.|..|..|...|.:.:.|   :.|....|..|::....:| .::|.:|:
Mouse    94 EMLSFRDVAIDFSAGELECLEPAQWDLYRDVMLE---NFSHLVFLGFSFSKPLLVRFLEKNQELR 155

  Fly   203 QLLLEHINASHDP--EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHH 265
            .:..:   |:..|  ::||.|.||...|..::..|.||:....||.:.|.:|.|.:.....|.:|
Mouse   156 NVKRK---AATVPRGKKPYKCKECGKAFAKSSVLTQHLRIHTGEKPYTCDICDKAFSLPSILHNH 217

  Fly   266 VEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGT 330
            .:.:..|..::|.:|.|.|....:|..|.|.|..::.:||  ..|.:.|:....|..|:..|:|
Mouse   218 QKIHTGEKPYKCEVCGKAFLMPSTLTNHQKIHTGEKPYKC--EVCGKAFLMPSTLTNHQKIHTG- 279

  Fly   331 SSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAI 395
              .|...|..|||.|........| .|.|.|||||||..|.:.|::     :..|.||:...|..
Mouse   280 --EKPYECEVCGKKFSSPADFTKH-QRVHTGEKPYKCEECKKPFSN-----LSALSRHKVVHTGE 336

  Fly   396 ERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNM 460
            :|..|..|.:.:|....|..|..|...|:.                       ::|..|.:.|..
Mouse   337 KRYTCEKCGKAYSRSYHLSRHKKAHSGQKS-----------------------YKCKECGKMFYY 378

  Fly   461 KSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHR 525
            .|.|:||..:||| :||:.|..|.|.|....|:..|.:||::.|...||.||:.|.::...:..|
Mouse   379 SSDLKRHQRIHSE-ERPYECEECGKAFPSPSDVTQHARTHKRMKQYTCDECGECFTIQTTFSNLR 442

  Fly   526 LSHEVLE-KNFKCNVCGRAY 544
            ...  || |..:|..|.:.:
Mouse   443 KIR--LEGKPSECERCRKDF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	2/8 (25%)
		COG5048	198..>508	CDD:227381	88/311 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	2/8 (25%)
		C2H2 Zn finger	565..582	CDD:275368
Rslcan18	NP_001242981.1	KRAB	96..154	CDD:214630	15/60 (25%)
		KRAB	96..135	CDD:279668	11/41 (27%)
		COG5048	168..458	CDD:227381	95/326 (29%)
		C2H2 Zn finger	173..193	CDD:275368	7/19 (37%)
		zf-H2C2_2	186..209	CDD:290200	8/22 (36%)
		C2H2 Zn finger	201..221	CDD:275368	5/19 (26%)
		zf-H2C2_2	216..236	CDD:290200	5/19 (26%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		zf-H2C2_2	242..264	CDD:290200	7/23 (30%)
		C2H2 Zn finger	257..277	CDD:275368	5/21 (24%)
		zf-H2C2_2	270..294	CDD:290200	10/26 (38%)
		C2H2 Zn finger	285..305	CDD:275368	7/20 (35%)
		zf-H2C2_2	297..322	CDD:290200	12/25 (48%)
		C2H2 Zn finger	313..333	CDD:275368	6/24 (25%)
		zf-H2C2_2	325..350	CDD:290200	7/24 (29%)
		C2H2 Zn finger	341..361	CDD:275368	5/19 (26%)
		zf-H2C2_2	353..378	CDD:290200	7/47 (15%)
		zf-C2H2	367..389	CDD:278523	7/21 (33%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		zf-H2C2_2	381..404	CDD:290200	11/23 (48%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100