DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp708

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001012325.2	Gene:	Zfp708 / 432769	MGIID:	3040674	Length:	541	Species:	Mus musculus

Alignment Length:	528	Identity:	137/528 - (25%)
Similarity:	225/528 - (42%)	Gaps:	85/528 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 IEIFVDA------------VDIDEAEEEEE--EEEQQQQYDEEVEEPITD-------ESAPPQLT 184
            ||:|::|            |.||.:.:|.|  :..|...|.|.:.|..::       .|.|..:|
Mouse     3 IEVFINAKEMTKDPLSFTDVAIDFSADECECLDSAQWNLYKEVMLENYSNLVFLGLAFSKPYLVT 67

  Fly   185 I-----------------------SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEA 226
            .                       ::.||.|   .:::....:|::| ...|..|:||.|.||..
Mouse    68 FLEQSSDLWSVKRKASVAIHLGSKAHKCKEC---GKSFDRNSVLIQH-QRIHTGERPYKCEECGM 128

  Fly   227 RFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLN 291
            .|......:.|.:....||.:.|..|||.:....||..|.:.:..|..::|..|.|.|.....|.
Mouse   129 AFTGRCILSKHQRIHTGEKPYKCKECGKAFSCSSNLHQHQQIHREEKPYKCDDCGKAFSCSSYLY 193

  Fly   292 YHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIY 356
            .|.:.|...:.:||:.  |.:.|....:|:.|:..|:|   .|...||.|||.|....|...| .
Mouse   194 KHQRIHTGMKPYKCKE--CGKAFNCSANLIYHQRIHTG---EKPYKCGECGKAFTIYSTFMNH-Q 252

  Fly   357 RQHGGEKPYKCANCTEVFAS----YAEKRIHM-------------------LERHRENLTAIERS 398
            |.|.|||||:|.:|.:.|.:    ...:|||.                   |::|:...|..:..
Mouse   253 RTHSGEKPYECKDCGKAFTNCYNLIQHQRIHTGEKPYACEECGKSFNYSSHLKQHKRIHTGEKPY 317

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPII---ANNKRVLQQKRERQYSG--LFQCGSCSQRF 458
            :|.:|.:.|:....|:.|......::|....:   |.:......|.:|.::|  .::|..|.:.|
Mouse   318 KCEVCGKAFNCSDYLVKHQRIHTGEKPYKCEVCGKAFSFSTYLHKHQRIHTGEKRYRCEECGKAF 382

  Fly   459 NMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQ 523
            ...|.|..|..||: .::|:.|..|.|.|.....:..|.:.|.:|:|..||.|||.|::....::
Mouse   383 TNYSGLIVHRRVHT-GEKPYKCEECGKAFSVHTSLSKHQRIHTREQPYKCDECGKTFSVHSTFSK 446

  Fly   524 HRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA 588
            |::.| ..||.:||..|.:.:.:...|..|:|.|||:..|||::|.:.|.:...||.|. :.|..
Mouse   447 HQIMH-TREKPYKCKHCDKTFKYPSPLVQHERIHTGERPYKCEVCGKAFTSSSNLKYHW-RLHTG 509

  Fly   589 SQPHSADQ 596
            .:|:..:|
Mouse   510 EKPYKCEQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/337 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp708	NP_001012325.2	KRAB	17..77	CDD:214630	12/59 (20%)
		KRAB	17..56	CDD:279668	9/38 (24%)
		C2H2 Zn finger	95..115	CDD:275368	5/23 (22%)
		COG5048	119..540	CDD:227381	114/408 (28%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		zf-H2C2_2	136..160	CDD:290200	7/23 (30%)
		C2H2 Zn finger	151..171	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		zf-H2C2_2	191..216	CDD:290200	7/26 (27%)
		C2H2 Zn finger	207..227	CDD:275368	5/21 (24%)
		zf-H2C2_2	219..243	CDD:290200	10/26 (38%)
		C2H2 Zn finger	235..255	CDD:275368	9/20 (45%)
		zf-H2C2_2	248..272	CDD:290200	11/24 (46%)
		C2H2 Zn finger	263..283	CDD:275368	4/19 (21%)
		zf-H2C2_2	275..300	CDD:290200	3/24 (13%)
		C2H2 Zn finger	291..311	CDD:275368	2/19 (11%)
		zf-H2C2_2	303..328	CDD:290200	6/24 (25%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..355	CDD:290200	4/23 (17%)
		C2H2 Zn finger	347..367	CDD:275368	3/19 (16%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..411	CDD:290200	8/23 (35%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		zf-H2C2_2	415..439	CDD:290200	9/23 (39%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-H2C2_2	472..496	CDD:290200	11/23 (48%)
		C2H2 Zn finger	487..507	CDD:275368	6/20 (30%)
		C2H2 Zn finger	515..535	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100