DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and CG31365

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	129/637 - (20%)
Similarity:	217/637 - (34%)	Gaps:	164/637 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKL------------SHIYDKIDASSLEDD 102
            |.....|.||::||.:|..:......||..||.|:.||            |.::.| |....::|
  Fly    47 LDAKATDTLPKRICQECRYQLEKSFLFRQRCQWAEKKLRKHIRLLGLGKRSRVFSK-DPDDYDED 110

  Fly   103 EIGQED-------------------LEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAV 148
            |:..||                   .|..:|.|..|..|.......|.:...|.....|:   |.
  Fly   111 ELEFEDSIAFIEVQDKVRKLEDEKWREDFKEEQAAEMHKRLVKSRLELRAKLTTELRKEL---AE 172

  Fly   149 DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINA-- 211
            ::.....:|..||.:.|..:::...::::....||.:...           :|:..|.|....
  Fly   173 EVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKEQLAMLLG-----------ELEVYLTEKKAGRW 226

  Fly   212 -SHDPEQPYNCPECEARFQDAA-SRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETD 274
             |.|..:|...|:.:   :||: ||:   |:..:.|:....|      |.:.......|...|.:
  Fly   227 ESLDGSEPETKPQVK---EDASPSRS---KTKALPKRRPSLV------DANLKATEARKDAKEEE 279

  Fly   275 FECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG 339
            |... |..               :|.........|.|        |.......||...|:   ..
  Fly   280 FILG-CNT---------------DPANNSDVNIDGLE--------LDEEVPAESGEDFRE---IN 317

  Fly   340 FCGKTFIHLKTLRWHIYR--------------------------------QHGGEKPYKCANCT- 371
            ..|...:|......:|..                                |..||||.:..:..
  Fly   318 MVGSDVVHTDNGEIYIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVV 382

  Fly   372 -----------EVFASYAEKRIHMLERH---RENLTAIER---SECML-----CRQPFSSE-PDL 413
                       :||:.:  :.:.::|:.   |:..|.::|   ||.:.     |.||.:.. .|.
  Fly   383 FNLGEEISQEQQVFSFH--ENVIIVEKEQNDRDEQTPLKRKRSSELVFKQESSCPQPKTGRITDT 445

  Fly   414 IHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL-------FQCGSCSQRFNMKSALERHAAVH 471
            :..... ||    .|:....:::|.:.......||       .:|.||:.:.:..|:|:||..:|
  Fly   446 VKSFQC-HL----CPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIH 505

  Fly   472 SEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH--RLSHEVLEKN 534
            :.. :|..|..|...|.:.:.:|.|:.||...|.:.|..|...||.|..|.||  |: |....:.
  Fly   506 TGL-KPFKCSECELSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRV-HMGNSRT 568

  Fly   535 FKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .||::|.|::.....|..|..||.| ..:.|..|..:|.....::.|:...|
  Fly   569 HKCHLCHRSFNHVSGLSRHLVTHAG-VMFSCKQCGRQFNDRSAVQRHVTTMH 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	12/36 (33%)
		COG5048	198..>508	CDD:227381	69/376 (18%)
		C2H2 Zn finger	221..241	CDD:275368	6/20 (30%)
		C2H2 Zn finger	249..269	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	1/19 (5%)
		C2H2 Zn finger	305..327	CDD:275368	3/21 (14%)
		C2H2 Zn finger	338..359	CDD:275368	3/52 (6%)
		C2H2 Zn finger	367..384	CDD:275368	2/28 (7%)
		C2H2 Zn finger	400..420	CDD:275368	4/25 (16%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/21 (43%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	14/38 (37%)
		vATP-synt_E	109..>244	CDD:304907	26/151 (17%)
		RRF	<161..222	CDD:294170	12/74 (16%)
		zf-C2H2_8	454..530	CDD:292531	17/76 (22%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	8/25 (32%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	9/21 (43%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030