DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp950

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001296145.1	Gene:	Zfp950 / 414758	MGIID:	2652824	Length:	609	Species:	Mus musculus

Alignment Length:	583	Identity:	154/583 - (26%)
Similarity:	223/583 - (38%)	Gaps:	142/583 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTA---SDPIEIFVDAVDIDEAEEEEEEEEQ 162
            ||...:|..:.:..|...||:.|....|..|......   |.|                     |
Mouse    48 DDHNIEEHCQSSRRHGRHETSHPGEKPSQYTHCGKAFVYWSHP---------------------Q 91

  Fly   163 QQQYDEEVEEPITDESAPPQLTISYACKFC---LRPQENYQLQQLLLEHINASHDPEQPYNCPEC 224
            :.:.....|:|             |.|..|   .....|.|..:.:       |..|:||.|.:|
Mouse    92 RHERIHTGEKP-------------YGCNHCGKAFAHHSNLQRHERI-------HTGEKPYECNQC 136

  Fly   225 EARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKS 289
            ...|...:...:|.::...||.:.|..|||.:....||:.|...:..|..:||..|.|.|....:
Mouse   137 GKAFVTHSDLQIHKRTHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNQCGKAFAYHSN 201

  Fly   290 LNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWH 354
            |..|.:.|..::.::|  :.|.:.|....||..||.||:|   .|...|..|||.|.|...|  |
Mouse   202 LQRHERIHTGEKPYEC--NKCGKAFAWHSHLQRHEITHTG---EKPYECNQCGKAFAHDSNL--H 259

  Fly   355 IY-RQHGGEKPYKCANCTEVFASY----AEKRIH-------------------MLERHRENLTAI 395
            |: |:|.|||||:|..|.:.|..|    ..||.|                   .|:.|....|..
Mouse   260 IHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMHERIHTGE 324

  Fly   396 ERSECMLCRQPFSSEPDL-IH-----------------------HMSAEHLQRPG-APIIAN--- 432
            :..||..|.:.||....| :|                       |:........| .|...|
Mouse   325 KPYECNHCGKAFSQHSSLRVHKRTHTGEKPYECNQCGEAFVYHSHLQIHKTMHTGEKPFQCNQCD 389

  Fly   433 -----NKRVLQQKR----ERQY------------SGL------------FQCGSCSQRFNMKSAL 464
                 |..:|..||    |:.|            |||            ::|..|.:.|...|.|
Mouse   390 KAFVYNNHLLVHKRIHTGEKPYECNHCGKAFSQLSGLHVHKRTHTGEKPYKCNECGKAFARNSHL 454

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            :||..:|: .::||.|..|.|.|.|...::.|.:.|..|||..|:.|||||....:|..|:.:|
Mouse   455 QRHKRIHT-GEKPHECNQCGKAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHKRTH- 517

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            ..||.::||.||:.:.:...|::|.|.|||:..|||:.|.:.|..|..|:.|.:| |...:|:
Mouse   518 TGEKPYECNQCGKTFAYHSHLQVHGRIHTGEKPYKCNQCGKAFACHRNLRVHKRK-HTGEKPY 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	105/394 (27%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	10/21 (48%)
		C2H2 Zn finger	367..384	CDD:275368	7/39 (18%)
		C2H2 Zn finger	400..420	CDD:275368	7/43 (16%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp950	NP_001296145.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	78..97	CDD:275368	4/39 (10%)
		COG5048	101..514	CDD:227381	116/440 (26%)
		C2H2 Zn finger	105..125	CDD:275368	4/26 (15%)
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		C2H2 Zn finger	217..237	CDD:275368	7/21 (33%)
		C2H2 Zn finger	245..265	CDD:275368	10/21 (48%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		C2H2 Zn finger	301..321	CDD:275368	2/19 (11%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		C2H2 Zn finger	357..377	CDD:275368	1/19 (5%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		C2H2 Zn finger	413..433	CDD:275368	3/19 (16%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	553..573	CDD:275368	7/20 (35%)
		C2H2 Zn finger	581..601	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100