DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and CG18476

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_731615.1	Gene:	CG18476 / 41404	FlyBaseID:	FBgn0037931	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	945	Identity:	186/945 - (19%)
Similarity:	284/945 - (30%)	Gaps:	389/945 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CRTCAISMFVCDFENGSNNSHFLDLHHPN-CWPSE-MAQIRLQFANWNLKISPNDGLPQKICSDC 66
            ||||          :.::..:.|.|..|: .:|.: :::|..:....||..:.:...||.:||.|
  Fly     7 CRTC----------DSTDTDNLLKLATPSKKYPDKLLSEILCELTEINLDATGSQKFPQCLCSGC 61

  Fly    67 FTK----FCSINAFRLA------------------C-QEAQLKL---SHIYDKIDASSLEDDEIG 105
            ..|    :|.:.....|                  | |||.::|   .|:..|::.   ||::.|
  Fly    62 TKKLMGAYCYVKQAMAANELLMKHLKNGAAPTSTDCLQEAPMELCAEQHVEVKLET---EDEDCG 123

  Fly   106 QEDL--------EPAEEHQET-ETTKPTT---TVSAETQPNNTA----SDPIEIFVDAVDID--- 151
            :.|:        ||.|...|: ::..|.|   ||..|.:|.:..    .||...|.|...:|
  Fly   124 ENDVTITCSELPEPDETDMESKKSVDPLTMIETVKLEMEPRSVEKPAYDDPTSDFEDEDSLDNLP 188

  Fly   152 -------------------EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRP-- 195
                               :.....:..:..::::..|.:|.|.         .|.|..|:|.
  Fly   189 LYNRIQKWKTGRKSVYKCHDCPRSFKRFDFLKRHEMRVHKPETR---------LYDCSLCIRKFS 244

  Fly   196 ------------------------------------------------QENY----QLQQLLLEH 208
                                                            |..|    .|::.|.||
  Fly   245 RSEALEAHLKIHRNSKRSANISEHKKAKAVDLNLCKPHGYKLIECMICQSQYNKIADLRRHLEEH 309

  Fly   209 ----------------------------------------------------------------- 208

  Fly   310 PDIVSLCGRPNMEPHELAELFYPDSKDLSEEQLINLIRKDLAAGIYQRFYSITNQSGYEMDLDSS 374

  Fly   209 -----INASHDPEQ---------PYNCPECEARFQDAASRTVHLKSSH--VEKQHACGVCGKKYG 257
                 ::..||.:.         .|:|..|:.:|........|.:.||  .:..|.||.|..::.
  Fly   375 ETDSDLDGDHDDQHKRRKKSRKATYSCELCQQKFPRKYQLYDHQRQSHSWSDAPHVCGRCDGRFV 439

  Fly   258 DRHNLRHHVEKY--HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQ-FKCRHSGCERLFISQRH 319
            ....||||.|..  :::..|.|..|..||..:.:|..|.:.|....| |:|  |.|:|:|..::.
  Fly   440 SLQLLRHHNESQCRNAQKRFLCHKCPLRFRWKHNLKTHFREHRITNQTFEC--SECKRVFDKKKS 502

  Fly   320 LMCH-EATHSGTSSRKSEHCGFCGKTFIH----LKTLRWHIYRQH---------------GGEKP 364
            |..| .:.|:..|  |...|.:|.:.|..    :|.|:.|..::|               .|.|.
  Fly   503 LTVHLLSVHAEES--KLIPCQWCSRKFYRHDYLVKHLKRHGLKEHDIPLAETLIAATSRPNGAKR 565

  Fly   365 YKCANCTEVFASYAEKRIHM-LE-------------RHRENLT-------AIERSE--------- 399
            ..|..|...|....:.|.|: ||             .|..::|       .:|.||
  Fly   566 ITCRMCNLHFERIVDLRAHIQLELKLSLSLHQSYDSPHNYSITNESGFELQLEDSETEDEMQPGV 630

  Fly   400 -------CMLCRQPFSSEPDLIHHMSAEHL-----------------------QRPGAPIIANNK 434
                   |.||......:.::|.|....|.                       .|.|.......|
  Fly   631 GSRPVYICELCSVQCKRKFEMIQHQRTMHRFDKMPHECDDCIFKCVSKSIMDHHRQGQCSSTEKK 695

  Fly   435 RV-------------LQQ----------------KRERQYSG------------LFQCGSCSQRF 458
            ..             |:|                .|..|.:|            |.||..|.:.:
  Fly   696 HACGKCSYKFMWPENLEQHILLQHSKSSVSNPTGDRHTQGTGDLEKDATEDGIPLLQCPHCDRTY 760

  Fly   459 NMKSALERHAA-VHSEKDR-----------------------------------PHACPHCSKRF 487
            .|||.|..|.. ||...||                                   |..|..|...|
  Fly   761 QMKSRLNNHIRDVHINGDRKRKEAIKRFLCSLCGMETRSAAALVTHMRRHTGEKPFKCDLCEMAF 825

  Fly   488 KRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRL 552
            .|..::..|.:.|..|||..|.||||.||....|.:|.|:|..| |..||..|.::|...|.|:|
  Fly   826 PRHSELASHRRMHTGEKPFHCTVCGKDFARSDKLKRHMLTHSGL-KPHKCTYCEKSYRQAKDLKL 889

  Fly   553 HQRTHTGKTYYKCDLCQERFVTHIKLKTH-MQKAH 586
            |.:.|||:..:.|..|.|||:....|:.| :.:.|
  Fly   890 HLQQHTGECPFVCGTCGERFIQSSTLEKHRLMRRH 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	23/107 (21%)
		COG5048	198..>508	CDD:227381	101/554 (18%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/22 (32%)
		C2H2 Zn finger	338..359	CDD:275368	6/24 (25%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/20 (35%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	7/17 (41%)
CG18476	NP_731615.1	zf-AD	6..84	CDD:285071	19/86 (22%)
		C2H2 Zn finger	206..227	CDD:275368	0/20 (0%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	401..422	CDD:275368	4/20 (20%)
		C2H2 Zn finger	431..447	CDD:275368	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	490..511	CDD:275368	7/22 (32%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	638..659	CDD:275368	5/20 (25%)
		C2H2 Zn finger	668..690	CDD:275368	2/21 (10%)
		C2H2 Zn finger	698..715	CDD:275368	2/16 (13%)
		C2H2 Zn finger	753..774	CDD:275368	7/20 (35%)
		C2H2 Zn finger	790..810	CDD:275368	0/19 (0%)
		zf-H2C2_2	802..825	CDD:290200	3/22 (14%)
		COG5048	814..>886	CDD:227381	27/72 (38%)
		C2H2 Zn finger	818..838	CDD:275368	5/19 (26%)
		zf-H2C2_2	830..855	CDD:290200	11/24 (46%)
		C2H2 Zn finger	846..866	CDD:275368	10/19 (53%)
		zf-H2C2_2	859..883	CDD:290200	10/24 (42%)
		C2H2 Zn finger	874..894	CDD:275368	7/19 (37%)
		C2H2 Zn finger	902..924	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1302
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050