DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and topi

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	714	Identity:	146/714 - (20%)
Similarity:	245/714 - (34%)	Gaps:	224/714 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 QLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQET-ETTKPTTTVSAETQ--------PNNTASD 139
            ::|:|..|...:.....|.::..:||:|......| |:|.....:.:..:        |......
  Fly     2 KVKVSGEYTLAEIEVELDQQLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPM 66

  Fly   140 PIEIFVDAVDIDEA-EEEEEEEEQQQQYDEEVEE--------PITDESAPPQLTISYACKFCLRP 195
            |.::.|:....|.| ::..:|.:.::.:|.:.|:        .:|......:.::.:..:
  Fly    67 PTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSR----- 126

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAA-------SRTVHLKSSHVEKQHAC---- 249
                         .|:|........||.|..:|...|       ::.:.:.....||.|..
  Fly   127 -------------SNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVS 178

  Fly   250 ---GVCGKKYGDR------HNLRHHVE---KYHSETDF------------ECALCEKRFYTRKSL 290
               ....|...:|      ..||.:::   ||...|..            ||.:|:::|.....|
  Fly   179 APPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGL 243

  Fly   291 NYHMKWHNPDR-------------------QFKCRHSGCERLF----ISQRHLMCHEATHS---- 328
            ..||:.|..|.                   ..||  :.|.|:|    ::.||.:.|::.||
  Fly   244 VRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKC--NSCGRIFYDPQVAFRHGLIHDSEHSTMRQ 306

  Fly   329 -----------------------------------GTSSRKSE-----------HCGFCGKTFIH 347
                                               .|:..|.|           .|.||...|..
  Fly   307 SPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFAD 371

  Fly   348 LKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH-------MLERHRE-NLTAIERSECMLCR 404
            :..|..| ...|..|:.::|..|.....:..|..||       |.|..|. |:|......|.:|.
  Fly   372 IAELLVH-SASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCE 435

  Fly   405 QPFSSEPDLI--HHMSAEH----LQRPGAPII-------------------ANNKRVLQQKRE-- 442
            ..|:: .||:  |..::.|    |...|..::                   :..|.:.::|||
  Fly   436 LKFAN-TDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKE 499

  Fly   443 ---------RQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHAC--PHCSKRFKRAQDMKWH 496
                     |||    .|..|.:.:...|.|.:|...| :..:|..|  .:|.::|....|:..|
  Fly   500 TRNTGAGRIRQY----LCDICGKSYTQSSHLWQHLRFH-QGVKPFVCQEENCDRKFTIRPDLNDH 559

  Fly   497 I-KTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            | |.|..|:|.:|.||||.|....|..||||.|.. |:.::|..||:.:....:|:.|||.|||:
  Fly   560 IRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRG-ERRYECEECGKRFYRADALKNHQRIHTGE 623

  Fly   561 TYYKCDLCQERF-------------VTHI----KLKTHMQK------AHAASQPHSADQPLDDL 601
            ..|.|..|.:.|             .:|:    :|...|||      |...:|.|:.:|..:|:
  Fly   624 KPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQQDNDV 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	0/2 (0%)
		COG5048	198..>508	CDD:227381	90/464 (19%)
		C2H2 Zn finger	221..241	CDD:275368	5/26 (19%)
		C2H2 Zn finger	249..269	CDD:275368	4/35 (11%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/25 (28%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	5/23 (22%)
		C2H2 Zn finger	400..420	CDD:275368	6/21 (29%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/22 (32%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/33 (15%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/21 (29%)
		C2H2 Zn finger	431..453	CDD:275368	6/22 (27%)
		COG5048	<450..647	CDD:227381	54/202 (27%)
		C2H2 Zn finger	469..490	CDD:275368	0/20 (0%)
		zf-C2H2	511..533	CDD:278523	6/25 (24%)
		C2H2 Zn finger	513..564	CDD:275368	14/51 (27%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	11/19 (58%)
		zf-H2C2_2	585..609	CDD:290200	9/24 (38%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930