DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and E(var)3-9

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_649852.2	Gene:	E(var)3-9 / 41073	FlyBaseID:	FBgn0260243	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	148/692 - (21%)
Similarity:	242/692 - (34%)	Gaps:	229/692 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METCRTCAISMFV-CDFEN-------GSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDG 57
            :|.||||.|...: .|.:.       ||:::...|          ||:|..|..:||:|::..||
  Fly    15 IEPCRTCGIYFTMGMDMDQAIVKPIFGSDDAAVAD----------MAEILEQMNDWNIKVAREDG 69

  Fly    58 LPQKICSDCFTKFCSINAFRLACQEAQLKLSHI-YDK----------IDASS--------LEDDE 103
            .||.:|..|..:|..:..|:.:|.|.|.:...: |.:          |:...        |:.||
  Fly    70 RPQYMCIACIAEFHRLIKFKRSCVETQEQFGELEYQREHNGIVIKREIEPEEEKFCGFIYLDTDE 134

  Fly   104 IGQEDLEPA---------------EEH------QETETTKPTTTVSAETQPNNTASDPIEIFVDA 147
            ....|.:.:               |||      |.::..:|       .:|.|.|| |::...|.
  Fly   135 EDNSDEDGSRRVCAVFDIPHVPIKEEHMARVPLQNSDKFQP-------PEPKNFAS-PVDSRFDM 191

  Fly   148 VDID----------------------EAEEEEEEEEQQQQYDEEVEEPITDESA---PPQLTISY 187
            :|.|                      |.|||||||..:..||::     .|.:|   ||..:...
  Fly   192 IDNDALTSGMLGPSIEDLSGTVDDGTEDEEEEEEEIVRFTYDDD-----NDAAAPLPPPLYSPVV 251

  Fly   188 ACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVC 252
            .||.|.                         |..|:.:|..:       |::.:|:.|...|.:|
  Fly   252 CCKLCF-------------------------YESPDQDAHME-------HMRRTHLLKDWECHIC 284

  Fly   253 GKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI-- 315
            |||:.:....|                          :.:|:|:|...|..||...|    ||
  Fly   285 GKKFTNAQESR--------------------------IKFHIKYHKLQRHVKCPVCG----FICS 319

  Fly   316 SQRHLMCH-EATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQH--GGEKPYKCANCTEVFASY 377
            |:..|..| :|.|..|.      |.:|||| :...||..|: ::|  .||     |...:.....
  Fly   320 SKETLKEHKQAVHVRTK------CTYCGKT-VKNATLHAHL-KKHLEEGE-----AELAQQLKKL 371

  Fly   378 AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKR- 441
            .:..:::..:|   |:::|.|   :.....:||...|          ||...:..:..|.:...
  Fly   372 EQLPVNLQSQH---LSSLESS---VAEVTTASEGSNI----------PGESTVPEDSNVTENSSV 420

  Fly   442 ---ERQYSGLFQC--GSCSQRFNMKSALERHAAVHSEKDRP----HACPHCSKRFKRAQDMKWHI 497
               |.......||  |..:     ...:...|.|.|....|    ..|.:||..|::||.::.|:
  Fly   421 PSIETSNHADIQCPMGPPA-----NGEVPDVADVASPSTEPTESVTKCSYCSDTFEKAQQLQAHV 480

  Fly   498 -KTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGR-AYLFEKSLRL----HQRT 556
             .||.:.:........::...|  .||...:..:.:...|..:..: ..:.|.|.:|    .|.:
  Fly   481 LATHTQTRKRRRSSDNQSLVRK--TTQEIPTSPIAKITKKQTIESKERVVLESSSQLDSTAQQES 543

  Fly   557 HTG--------------KTYYKCDLCQERFVTHIKLKTHMQK 584
            .|.              |.|..|.:|...|...|||..|:::
  Fly   544 RTSATSNDSSPVQQVPEKAYISCYICGRSFDLKIKLNRHLKQ 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	27/91 (30%)
		COG5048	198..>508	CDD:227381	66/325 (20%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	305..327	CDD:275368	8/24 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	3/21 (14%)
		C2H2 Zn finger	480..500	CDD:275368	7/20 (35%)
		C2H2 Zn finger	508..528	CDD:275368	3/19 (16%)
		C2H2 Zn finger	537..557	CDD:275368	4/24 (17%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
E(var)3-9	NP_649852.2	zf-AD	18..102	CDD:285071	27/93 (29%)
		zf-C2H2_2	253..>334	CDD:289522	29/142 (20%)
		C2H2 Zn finger	253..274	CDD:275368	7/52 (13%)
		C2H2 Zn finger	281..303	CDD:275368	8/47 (17%)
		PHA00732	310..>358	CDD:177300	20/59 (34%)
		C2H2 Zn finger	311..332	CDD:275368	8/24 (33%)
		C2H2 Zn finger	337..356	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000098
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000