DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp941

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001001180.2	Gene:	Zfp941 / 407812	MGIID:	3039601	Length:	671	Species:	Mus musculus

Alignment Length:	594	Identity:	136/594 - (22%)
Similarity:	225/594 - (37%)	Gaps:	144/594 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLAC------QEAQLKLSH--IYD 92
            |.::..||::.:    ||..|.|     ...|||..|:.:.:..|      .|...|||.  :.:
Mouse   188 SNISVARLEYKH----ISKCDQL-----ESSFTKKPSLCSKQTTCVKLHSVNERGQKLSRPSLLN 243

  Fly    93 KIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIE--------------- 142
            |...:::.|.:.|.|.:     .:||..|...:.:...:|.::|.....|
Mouse   244 KKKGTTIWDAKRGAESV-----CKETSQTVRQSGILNNSQDSSTGEKTYECTKTHKNFSGGSAHG 303

  Fly   143 --------IFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENY 199
                    :|......|.:.:..::.:.....||                 :|.|:.|:.   .:
Mouse   304 KRAPSLGNVFRGNKCGDVSHQSLKDLQSSHLQDE-----------------AYKCEGCVL---TF 348

  Fly   200 QLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRH 264
            :.:..|||| ..:|...:.|.|.||...|...:...||.:|...|..|.|..||:.:.....|..
Mouse   349 RQKSDLLEH-QKTHGRAKSYKCGECGKAFSSCSDLNVHQRSHDGENPHECKECGRAFASGRALAR 412

  Fly   265 HVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSG 329
            |...:..:..:.|..|.|.|....:||.|::.|..::.|||  ..|...|....||..|:..::|
Mouse   413 HQHTHTGKKSYICEECGKNFKKGSNLNQHLRIHTGEKPFKC--EDCGLAFNQSSHLAKHQRIYAG 475

  Fly   330 TSSRKSEHCGFCGKTFIHLKTLRWHIYRQHG---GEKPYKCANCTEVFASYAEKRIHMLERHREN 391
            .          ||::|:...|.|    |.|.   |.||:||..|.:.|...::
Mouse   476 E----------CGRSFVKCSTSR----RCHSIRPGAKPHKCKQCGKTFVDISK------------ 514

  Fly   392 LTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
                                 |..|.:....::|                       |:|..|.:
Mouse   515 ---------------------LTQHQNVHTGEKP-----------------------FKCNECGK 535

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .||...:|::|..||: .::|:.|..|.|.|.:...:..|.:.|..|||..|..|||||......
Mouse   536 AFNSGLSLKQHQVVHT-GEKPYKCKECEKAFTQIAKLTEHQRVHTGEKPYECKECGKAFRNFSAF 599

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            ..|..:| ..||.::|..||:|:.....|:.|.|.|:|:..|||:.|.:.|..::.|:.| |:.|
Mouse   600 NYHHRTH-TGEKPYECKECGKAFTKSSDLKRHHRIHSGEKPYKCNECGKAFAMNVSLREH-QRVH 662

  Fly   587 AASQPHSAD 595
            :..:|:..|
Mouse   663 SREKPYKRD 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/56 (23%)
		COG5048	198..>508	CDD:227381	73/312 (23%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp941	NP_001001180.2	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	316..333	CDD:275368	1/16 (6%)
		COG5048	322..>642	CDD:227381	98/414 (24%)
		C2H2 Zn finger	341..361	CDD:275368	6/23 (26%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	381..406	CDD:290200	8/24 (33%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..462	CDD:290200	9/26 (35%)
		C2H2 Zn finger	453..472	CDD:275368	6/20 (30%)
		C2H2 Zn finger	502..522	CDD:275368	5/52 (10%)
		zf-H2C2_2	515..539	CDD:290200	7/46 (15%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		zf-H2C2_2	542..567	CDD:290200	9/25 (36%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		zf-H2C2_2	571..595	CDD:290200	11/23 (48%)
		C2H2 Zn finger	586..606	CDD:275368	7/19 (37%)
		zf-H2C2_2	598..622	CDD:290200	8/24 (33%)
		C2H2 Zn finger	614..634	CDD:275368	7/19 (37%)
		zf-H2C2_2	626..650	CDD:290200	9/23 (39%)
		C2H2 Zn finger	642..662	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100