DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and CG11247

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	121/516 - (23%)
Similarity:	197/516 - (38%)	Gaps:	124/516 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KIDA-SSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEE 156
            |.|| |.|.|..|.......|.|      :.|..|::.:.:.::.||     ..||.    .:||
  Fly    10 KEDAVSLLTDSGISLSSPPAARE------SSPGPTLAIKRRKSSLAS-----LRDAC----VDEE 59

  Fly   157 EEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNC 221
            |::..:|...|::..:|...:||...                        |.:...|     :.|
  Fly    60 EDDGGEQDSKDDDYVQPQLKKSARKG------------------------EPVKRKH-----HVC 95

  Fly   222 PECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFY 285
            .:|...|........|:.....|:.|.|..|||.|....||::|:...|. ...|.|:.|.|.|.
  Fly    96 SQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFA 160

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            .::.|..||:.|:.::.:.|  ..|::.|.....|..|..:|..||.::
  Fly   161 LKERLRLHMRLHSGEKPYPC--DLCDKKFARGGQLQQHMVSHHKTSIQQ---------------- 207

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIH 415
                          :.|..|:..|::.|..|:|| |||.:.:    ...|.:|...|::|..|..
  Fly   208 --------------FNCTKCSASFSTNANLRVHM-ERHEQGM----EHRCSICENQFANELALRA 253

  Fly   416 HMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRF----NMKSALERHAAVHSEKDR 476
            |::.||             ..|.|         |:|..|.:..    ::.:.::||.||     :
  Fly   254 HINQEH-------------HKLTQ---------FECEICHKMIEPDEDLATHMQRHTAV-----K 291

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            .|.|..|:..|.:......|::.|..|:|..|.:|.:.||...||..|...| ..||.|:|.:|.
  Fly   292 THVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKH-TGEKPFRCQLCE 355

  Fly   542 RAYLFEKSLRLHQRTHTGKTY-----YKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQP 597
            ....|  |...|.:.|..|.:     |.|:.|.:.|...::|::|::  |.|..|...|:|
  Fly   356 DEVAF--SQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE--HCAKCPVDGDKP 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	69/314 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	0/20 (0%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/23 (22%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	46/200 (23%)
		C2H2 Zn finger	95..115	CDD:275368	4/19 (21%)
		zf-H2C2_2	107..132	CDD:290200	8/24 (33%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	7/25 (28%)
		C2H2 Zn finger	180..200	CDD:275368	5/21 (24%)
		COG5048	<192..369	CDD:227381	56/241 (23%)
		C2H2 Zn finger	210..230	CDD:275370	8/20 (40%)
		C2H2 Zn finger	238..260	CDD:275371	8/34 (24%)
		C2H2 Zn finger	267..287	CDD:275368	2/19 (11%)
		C2H2 Zn finger	295..315	CDD:275368	4/19 (21%)
		zf-H2C2_2	309..332	CDD:290200	7/22 (32%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/24 (29%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.980