DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF880

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001138906.1	Gene:	ZNF880 / 400713	HGNCID:	37249	Length:	577	Species:	Homo sapiens

Alignment Length:	482	Identity:	131/482 - (27%)
Similarity:	204/482 - (42%)	Gaps:	67/482 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 NNTASDPIEIFVDAV----------DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYA 188
            ||:...|::....:|          |.|::....:|::.|.:     |:|
Human   139 NNSLVSPLQKIYSSVKSHILNKYRNDFDDSPFLPQEQKAQIR-----EKP--------------- 183

  Fly   189 CKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            |: |....:.:::...|..: ...|..:.||.|.||:..|.::::...|.:....||.:.|..||
Human   184 CE-CNEHGKAFRVSSRLANN-QVIHTADNPYKCNECDKVFSNSSNLVQHQRIHTGEKPYKCHECG 246

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |.:.....|..|...:..|..::|..|.|.|.....|..|.:.|..::.:||..  |.::|....
Human   247 KLFNRISLLARHQRIHTGEKPYKCHECGKVFTQNSHLANHHRIHTGEKPYKCNE--CGKVFNRNA 309

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            ||..|:..|||   .|...|..|||.|.....|..|:. .|.|||.|||..|.:||    .:..|
Human   310 HLARHQKIHSG---EKPYKCKECGKAFSGGSGLTAHLV-IHTGEKLYKCNKCGKVF----NRNAH 366

  Fly   384 MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPG-APIIANNKRVLQQKRERQYSG 447
             |.||:...|..:..||..|.:.|..:..|.:|    |....| .|...|.    ..|..|..||
Human   367 -LTRHQRIHTGEKPYECKECGKVFRHKFCLTNH----HRMHTGEQPYKCNE----CGKAFRDCSG 422

  Fly   448 L------------FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH 500
            |            ::|..|::.|..:.:|..|...|: .::|:.|..|.|.|.|..::..|.:.|
Human   423 LTAHLLIHTGEKPYKCKECAKVFRHRLSLSNHQRFHT-GEKPYRCDECGKDFTRNSNLANHHRIH 486

  Fly   501 EKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKC 565
            ..|||..|..|.|.|:....|.:||..| ..||::|||.||:.:..:..|:.|:|.|||:..|:|
Human   487 TGEKPYKCSECHKVFSHNSHLARHRQIH-TGEKSYKCNECGKVFSHKLYLKKHERIHTGEKPYRC 550

  Fly   566 DLCQERFVTHIKLKTHMQKAHAASQPH 592
            ..|.:.|..:..|..| .:.|...:|:
Human   551 HECGKDFTRNSNLANH-HRIHTGEKPY 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/322 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF880	NP_001138906.1	KRAB	7..65	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	162..568	CDD:227381	125/449 (28%)
		C2H2 Zn finger	186..206	CDD:275368	2/20 (10%)
		zf-C2H2	212..234	CDD:278523	6/21 (29%)
		C2H2 Zn finger	214..234	CDD:275368	5/19 (26%)
		zf-H2C2_2	226..251	CDD:290200	7/24 (29%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		zf-H2C2_2	255..279	CDD:290200	7/23 (30%)
		C2H2 Zn finger	270..290	CDD:275368	6/19 (32%)
		zf-H2C2_2	282..307	CDD:290200	7/26 (27%)
		C2H2 Zn finger	298..318	CDD:275368	6/21 (29%)
		zf-H2C2_2	310..334	CDD:290200	11/26 (42%)
		C2H2 Zn finger	326..346	CDD:275368	7/20 (35%)
		zf-C2H2	352..374	CDD:278523	10/26 (38%)
		C2H2 Zn finger	354..374	CDD:275368	8/24 (33%)
		zf-H2C2_2	366..391	CDD:290200	9/25 (36%)
		C2H2 Zn finger	382..402	CDD:275368	6/23 (26%)
		C2H2 Zn finger	410..430	CDD:275368	6/23 (26%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
		zf-H2C2_2	450..475	CDD:290200	8/25 (32%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		zf-H2C2_2	478..503	CDD:290200	9/24 (38%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		zf-H2C2_2	506..531	CDD:290200	11/25 (44%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..559	CDD:290200	10/24 (42%)
		C2H2 Zn finger	550..570	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100